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GRM1 [plasma membrane]
Stable Identifier
R-HSA-420521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Metabotropic glutamate receptor 1, GRM1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Group I Metabotropic glutamate receptors:Glu [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
Metabotropic glutamate receptors bind glutamate (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
GRM1-8:L-Glu [plasma membrane] (Homo sapiens)
GRM1-8 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13255 GRM1
Gene Names
GRM1, GPRC1A, MGLUR1
Chain
signal peptide:1-18, chain:19-1194
Reference Genes
BioGPS Gene:2911 GRM1
COSMIC (genes):GRM1 GRM1
CTD Gene:2911 GRM1
dbSNP Gene:2911 GRM1
ENSEMBL:ENSG00000152822 GRM1
HGNC:4593 GRM1
KEGG Gene (Homo sapiens):2911 GRM1
Monarch:2911 GRM1
NCBI Gene:2911 GRM1
OMIM:604473 GRM1
UCSC:Q13255 GRM1
Reference Transcript
RefSeq:NM_001278067.1 GRM1
RefSeq:XM_017010786.1 GRM1
RefSeq:XM_011535782.1 GRM1
RefSeq:XM_017010787.1 GRM1
RefSeq:XM_017010784.1 GRM1
RefSeq:NM_001278064.1 GRM1
RefSeq:XM_017010783.1 GRM1
RefSeq:NM_001278066.1 GRM1
RefSeq:XM_017010785.1 GRM1
RefSeq:NM_001278065.1 GRM1
Other Identifiers
0003780441
11737999_a_at
11741117_a_at
11741118_a_at
17013385
207299_s_at
210939_s_at
210940_s_at
2911
2929582
2929585
2929586
2929587
2929588
2929613
2929630
2929644
2929645
2929648
2929650
2929652
2929657
2929660
2929661
2929662
2929663
2929664
2929665
2929666
2929667
2929668
2929669
2929670
2929671
2929672
2929673
31468_f_at
33509_at
33510_s_at
8122537
A_14_P101254
A_14_P113431
A_14_P113841
A_23_P30976
A_33_P3271965
GE79002
GO:0000186
GO:0000187
GO:0001640
GO:0003674
GO:0004930
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005886
GO:0005887
GO:0006464
GO:0006810
GO:0007165
GO:0007186
GO:0007196
GO:0007216
GO:0007267
GO:0007268
GO:0007626
GO:0008066
GO:0008150
GO:0014069
GO:0016020
GO:0016021
GO:0019233
GO:0030425
GO:0032991
GO:0038037
GO:0038038
GO:0042592
GO:0042802
GO:0043005
GO:0043226
GO:0043408
GO:0050877
GO:0051482
GO:0051930
GO:0051966
GO:0055085
GO:0060078
GO:0071257
GO:0098685
GO:0098712
GO:0098839
GO:0098872
GO:0098978
GO:0099530
GO:0099566
GO:0099583
HMNXSV003007309
ILMN_1670547
L76627_at
PH_hs_0002770
TC06001063.hg
U31215_s_at
U31216_s_at
g1477389_3p_a_at
g6006005_3p_a_at
g945098_3p_a_at
Participates
as a member of
GRM1,GRM5 [plasma membrane] (Homo sapiens)
GRM1,GRM5 [plasma membrane] (Homo sapiens)
Other forms of this molecule
GRM1(410-1194) [plasma membrane]
Inferred To
mgl-2 [plasma membrane]
(Caenorhabditis elegans)
grm1a [plasma membrane]
(Danio rerio)
GRM1 [plasma membrane]
(Bos taurus)
GRM1 [plasma membrane]
(Canis familiaris)
GRM1 [plasma membrane]
(Gallus gallus)
GRM1 [plasma membrane]
(Sus scrofa)
grm1 [plasma membrane]
(Xenopus tropicalis)
Grm1 [plasma membrane]
(Mus musculus)
Grm1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_016866272.1
,
NP_001264994.1
,
XP_016866273.1
,
NP_001264995.1
,
XP_011534084.1
,
XP_016866274.1
,
XP_016866275.1
,
NP_001264996.1
,
NP_001264993.1
,
XP_016866276.1
ZINC - World Drugs
GRM1_HUMAN
Guide to Pharmacology - Targets
289
OpenTargets
ENSG00000152822
ZINC - FDA approved
GRM1_HUMAN
ZINC - Substances
GRM1_HUMAN
ZINC target
Q13255
ZINC - Biogenic
GRM1_HUMAN
PRO
Q13255
GlyGen
Q13255
PDB
7DGE
,
3KS9
,
4OR2
,
7DGD
ZINC - Investigational
GRM1_HUMAN
ZINC - Metabolites
GRM1_HUMAN
HPA
ENSG00000152822-GRM1
GeneCards
Q13255
Ensembl
ENST00000361719
,
ENST00000282753
,
ENSP00000424095
,
ENST00000492807
,
ENSP00000425599
,
ENST00000507907
,
ENSP00000347437
,
ENSP00000354896
,
ENSP00000282753
,
ENSG00000152822
,
ENST00000355289
Pharos - Targets
Q13255
Orphanet
21875
ZINC - Predictions - Purchasable
GRM1_HUMAN
HMDB Protein
HMDBP02215
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.524
2
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