Reactome | PVR [plasma membrane]

PVR [plasma membrane]

Stable Identifier

R-HSA-420600

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Necl-5/PVR

Locations in the PathwayBrowser for interactor UniProt:Q8NBD8 T229B

Expand all

External Reference Information

External Reference

UniProt:P15151 PVR

Gene Names

PVR, PVS

Chain

signal peptide:1-20, chain:21-417

Reference Genes

BioGPS Gene:5817 PVR

COSMIC (genes):PVR PVR

CTD Gene:5817 PVR

dbSNP Gene:5817 PVR

ENSEMBL:ENSG00000073008 PVR

HGNC:9705 PVR

KEGG:hsa:5817 PVR

Monarch:5817 PVR

NCBI Gene:5817 PVR

OMIM:173850 PVR

UCSC:P15151 PVR

Reference Transcript

Other Identifiers

11719177_x_at

11719178_a_at

11719179_a_at

11737539_a_at

1556582_PM_at

1556582_at

16862996

212662_3p_at

212662_PM_at

212662_at

214443_PM_at

214443_at

214444_PM_s_at

214444_s_at

216283_PM_s_at

216283_s_at

32698_at

32699_3p_s_at

32699_PM_s_at

32699_s_at

3835646

3835647

3835648

3835650

3835651

3835652

3835653

3835656

3835657

3835658

3835659

3835660

3835661

3835662

3835663

3835664

3835666

3835667

3835668

3835669

3835670

3835671

3835676

3835677

3835678

4865428C_3p_s_at

5817

69681_at

8029437

83915_at

A_23_P141894

A_24_P65616

GE59904

GO:0001618

GO:0002860

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0005912

GO:0005925

GO:0007155

GO:0007156

GO:0007157

GO:0009986

GO:0016020

GO:0038023

GO:0042271

GO:0045954

GO:0046718

GO:0050839

GO:0060089

GO:0060370

HMNXSV003022646

HMNXSV003026660

HMNXSV003054357

Hs.171844.0.S1_3p_at

Hs.171844.0.S1_3p_s_at

Hs.171844.0.S1_3p_x_at

Hs.321018.0.S1_3p_a_at

Hs2.91202.1.S1_3p_at

ILMN_1677305

PH_hs_0010286

PH_hs_0039656

TC19000624.hg

Participates

as a component of

as an input of

Inferred To

igcm-3 [plasma membrane] (Caenorhabditis elegans)

Pvr [plasma membrane] (Mus musculus)

Fas3 [plasma membrane] (Drosophila melanogaster)

nectin1b [plasma membrane] (Danio rerio)

PVR [plasma membrane] (Canis familiaris)

PVR [plasma membrane] (Gallus gallus)

PVR [plasma membrane] (Rattus norvegicus)

PVR [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_006496.4, NP_001129241.1, NP_001129242.2, NP_001129240.1

Guide to Pharmacology - Targets

3095

OpenTargets

ENSG00000073008

ENSEMBL

ENSP00000385344, ENST00000344956, ENSP00000340870, ENST00000403059

HPA

ENSG00000073008-PVR

PRO

P15151

Pharos - Targets

P15151

GlyGen

P15151

PDB

6O3O, 3EPD, 6ARQ, 4FQP, 1DGI, 1NN8, 3J9F, 3EPF, 3EPC, 3J8F, 6ISC, 3URO, 3UDW

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.781	11
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.718	6
UniProt:Q15762 CD226	1	CD226 [plasma membrane] (R-HSA-197562)	0.676	3
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.666	4
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:Q8K4F0	1	Cd226 [plasma membrane] (R-MMU-197562)	0.618	3
UniProt:Q495A1 TIGIT			0.609	2
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:Q96MV8 ZDH15			0.556	3
UniProt:Q04941 PLP2			0.556	3
UniProt:Q6PI78 TMM65			0.556	3
UniProt:Q4LDR2 CTXN3			0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:Q8NBI2 CYAC3			0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:O43934 MFS11			0.556	3
UniProt:Q969K7 TMM54			0.556	3
UniProt:P56851 EP3B			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:P55061 BI1			0.556	3
UniProt:Q6PL45-2 BRICD5			0.556	3
UniProt:Q08722-3 CD47			0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:Q8N2H4 SYS1	1	SYS1 [trans-Golgi network membrane] (R-HSA-6813921)	0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:Q8N966 ZDH22			0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q9BSE2 TMM79			0.556	3
UniProt:Q9HCP6 HHATL			0.556	3
UniProt:Q9BYQ3 KRTAP9-3	1	KRTAP9-3 [cytosol] (R-HSA-6809954)	0.556	3
UniProt:Q9BZW4 TM6S2			0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:Q96PS8 AQP10	1	AQP10 [plasma membrane] (R-HSA-431709)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:P59542 TAS2R19	1	TAS2R19 [plasma membrane] (R-HSA-3299625)	0.556	3
UniProt:Q9Y5U4 INSIG2	1	INSIG2 [endoplasmic reticulum membrane] (R-HSA-1655736)	0.556	3
UniProt:Q5BVD1 TTMP			0.556	3
UniProt:Q96JW4 SLC41A2	1	SLC41A2 [plasma membrane] (R-HSA-442666)	0.556	3
UniProt:P30536 TSPO	1	TSPO [mitochondrial outer membrane] (R-HSA-2980957)	0.556	3
UniProt:Q92982 NINJ1			0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:P0DJD7 PGA4	1	PGA4 [multivesicular body lumen] (R-HSA-5685891)	0.556	3
UniProt:P0DTL5 TM276			0.556	3
UniProt:Q6UX06 OLFM4	3	OLFM4 [tertiary granule lumen] (R-HSA-6800893) OLFM4 [extracellular region] (R-HSA-6799672) OLFM4 [specific granule lumen] (R-HSA-6799634)	0.556	3
UniProt:Q8N6F1-2 CLDN19			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q5SQN1 SNP47			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.527	2

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