Reactome | FANCB [cytosol]

FANCB [cytosol]

Stable Identifier

R-HSA-420791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fanconi anemia group B protein, FANCB_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCB [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCB [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NB91 FANCB

Gene Names

FANCB

Chain

initiator methionine:, chain:2-859

Reference Genes

BioGPS Gene:2187 FANCB

COSMIC (genes):FANCB FANCB

CTD Gene:2187 FANCB

dbSNP Gene:2187 FANCB

ENSEMBL:ENSG00000181544 FANCB

ENSEMBL_homo_sapiens_GENE:ENSG00000181544.16 FANCB

HGNC:3583 FANCB

KEGG Gene (Homo sapiens):2187 FANCB

Monarch:2187 FANCB

NCBI Gene:2187 FANCB

OMIM:300515 FANCB

UCSC:Q8NB91 FANCB

Reference Transcript

Other Identifiers

11735300_a_at

1553244_PM_at

1553244_at

1557217_PM_a_at

1557217_a_at

1557218_PM_s_at

1557218_s_at

17109211

2187

4000386

4000387

4000388

4000389

4000390

4000391

4000392

4000393

4000395

4000397

4000398

4000403

4000404

4000405

4000406

4000408

8171381

A_23_P356021

GE600362

GO:0000785

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006281

GO:0006310

GO:0006974

GO:0036297

GO:0043226

GO:0043240

GO:1905168

GO:1990414

GO:2000042

HMNXSV003007108

Hs2.277254.1.S1_3p_at

Hs2.277254.2.S1_3p_s_at

ILMN_1698252

ILMN_1726756

PH_hs_0014239

TC0X000872.hg

Participates

as a component of

FA Core Complex [cytosol] (Homo sapiens)

Other forms of this molecule

FANCB [nucleoplasm]

Inferred To

FANCB [cytosol] (Bos taurus)

FANCB [cytosol] (Canis familiaris)

FANCB [cytosol] (Gallus gallus)

FANCB [cytosol] (Sus scrofa)

fancb [cytosol] (Xenopus tropicalis)

Fancb [cytosol] (Mus musculus)

Fancb [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_689846.1, NP_001018123.1, NP_001311091.1, XP_016884844.1

OpenTargets

ENSG00000181544

GeneCards

Q8NB91

HPA

ENSG00000181544-FANCB

Ensembl

ENSP00000512578, ENSP00000512550, ENSP00000512577, ENSG00000181544, ENST00000696356, ENSP00000498215, ENST00000696312, ENST00000696357, ENSP00000326819, ENST00000324138, ENST00000650831

PRO

Q8NB91

Pharos - Targets

Q8NB91

Orphanet

16021

PDB

7KZS, 7KZT, 7KZQ, 7KZV, 7KZR, 7KZP

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	2	FANCA [nucleoplasm] (R-HSA-419541) FANCA [cytosol] (R-HSA-420796)	0.643	4
UniProt:Q0VG06 FAAP100	2	FAAP100 [nucleoplasm] (R-HSA-419545) FAAP100 [cytosol] (R-HSA-420799)	0.556	4
UniProt:Q99615 DNAJC7	2	DNAJC7 [cytosol] (R-HSA-5252099) DNAJC7 [nucleoplasm] (R-HSA-5255408)	0.527	2
UniProt:P49746 THBS3	1	THBS3 [extracellular region] (R-HSA-66522)	0.527	2
UniProt:Q8IYD8 FANCM	3	FANCM [nucleoplasm] (R-HSA-419535) p-S1045-FANCM [nucleoplasm] (R-HSA-6788401) FANCM [cytosol] (R-HSA-420802)	0.527	2
UniProt:Q9NPD8 UBE2T	3	UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217)	0.527	2
UniProt:Q15435 PP1R7			0.508	2