Reactome | FAAP100 [cytosol]

FAAP100 [cytosol]

Stable Identifier

R-HSA-420799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fanconi anemia-associated protein of 100 kDa, FP100_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FAAP100 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FAAP100 [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FAAP100 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q0VG06 FAAP100

Gene Names

FAAP100, C17orf70

Chain

chain:1-881

Reference Genes

BioGPS Gene:80233 FAAP100

COSMIC (genes):FAAP100 FAAP100

CTD Gene:80233 FAAP100

dbSNP Gene:80233 FAAP100

ENSEMBL:ENSG00000185504 FAAP100

HGNC:26171 FAAP100

KEGG:hsa:80233 FAAP100

Monarch:80233 FAAP100

NCBI Gene:80233 FAAP100

OMIM:611301 FAAP100

UCSC:Q0VG06 FAAP100

Reference Transcript

Participates

as a component of

FA Core Complex [cytosol] (Homo sapiens)

Other forms of this molecule

FAAP100 [nucleoplasm]

Inferred To

faap100 [cytosol] (Danio rerio)

faap100 [cytosol] (Xenopus tropicalis)

FAAP100 [cytosol] (Bos taurus)

FAAP100 [cytosol] (Canis familiaris)

FAAP100 [cytosol] (Gallus gallus)

FAAP100 [cytosol] (Sus scrofa)

Faap100 [cytosol] (Mus musculus)

Faap100 [cytosol] (Rattus norvegicus)

Homologues of FAAP100 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016880651.1, XP_006722175.1, XP_016880652.1, NP_079437.5, XP_047292804.1

OpenTargets

ENSG00000185504

ENSEMBL

ENST00000327787, ENSG00000185504, ENSP00000333283

HPA

ENSG00000185504-FAAP100

GeneCards

FAAP100

PRO

Q0VG06

Pharos - Targets

Q0VG06

GlyGen

Q0VG06

PDB

7KZS, 7KZT, 7KZR, 7KZV, 7KZP, 7KZQ

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.662	4
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.643	5
UniProt:Q96KS9 F167A			0.643	3
UniProt:Q8NB91 FANCB	2	FANCB [cytosol] (R-HSA-420791) FANCB [nucleoplasm] (R-HSA-419528)	0.556	4
UniProt:Q8WVK7 SKA2	1	SKA2 [cytosol] (R-HSA-376231)	0.527	4
UniProt:Q9NPD8 UBE2T	3	UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217)	0.527	2
UniProt:O75638 CTAG2			0.527	3
UniProt:P99999 CYCS	6	CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P15407 FOSL1	1	FOSL1 [nucleoplasm] (R-HSA-9620405)	0.527	3
UniProt:Q96LR2 LURA1			0.527	2
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	2
UniProt:Q96T91 GPHA2	1	GPHA2 [extracellular region] (R-HSA-8942422)	0.527	2
UniProt:Q9UJT2 TSKS			0.527	2
UniProt:Q8NHQ8 RASF8			0.527	2
UniProt:Q969T3 SNX21			0.527	3
UniProt:Q53S33 BOLA3			0.499	2
UniProt:Q8WTQ7 GRK7	1	GRK7 [photoreceptor disc membrane] (R-HSA-6787797)	0.499	2
UniProt:Q9NW38 FANCL	2	FANCL [cytosol] (R-HSA-420789) FANCL [nucleoplasm] (R-HSA-419520)	0.482	2

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