Reactome | FANCM [cytosol]

FANCM [cytosol]

Stable Identifier

R-HSA-420802

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fanconi anemia group M protein, FANCM_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Antimicrobial mechanism of IFN-stimulated genes (Homo sapiens)
      - PKR-mediated signaling (Homo sapiens)
        
        FA core complex:HSP70s binds PKR (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCM:FAAP24 [cytosol] (Homo sapiens)
        
        FANCM [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCM:FAAP24 [cytosol] (Homo sapiens)
        
        FANCM [cytosol] (Homo sapiens)
        
        PKR forms a dimer (Homo sapiens)
        
        FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
        
        FA Core Complex:HSP70s [cytosol] (Homo sapiens)
        
        FA Core Complex [cytosol] (Homo sapiens)
        
        FANCM:FAAP24 [cytosol] (Homo sapiens)
        
        FANCM [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IYD8 FANCM

Gene Names

FANCM, KIAA1596

Chain

chain:1-2048

Reference Genes

BioGPS Gene:57697 FANCM

COSMIC (genes):FANCM FANCM

CTD Gene:57697 FANCM

dbSNP Gene:57697 FANCM

ENSEMBL:ENSG00000187790 FANCM

HGNC:23168 FANCM

KEGG:hsa:57697 FANCM

Monarch:57697 FANCM

NCBI Gene:57697 FANCM

OMIM:609644 FANCM

UCSC:Q8IYD8 FANCM

Reference Transcript

Participates

as a component of

FANCM:FAAP24 [cytosol] (Homo sapiens)

Other forms of this molecule

FANCM [nucleoplasm]

p-S1045-FANCM [nucleoplasm]

Inferred To

Fancm [cytosol] (Mus musculus)

Fancm [cytosol] (Rattus norvegicus)

fancm [cytosol] (Danio rerio)

fancm [cytosol] (Xenopus tropicalis)

FANCM [cytosol] (Bos taurus)

FANCM [cytosol] (Canis familiaris)

FANCM [cytosol] (Gallus gallus)

FANCM [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001295063.1, NP_001295062.1, NP_065988.1

OpenTargets

ENSG00000187790

ENSEMBL

ENST00000267430, ENST00000556036, ENSG00000187790, ENSP00000267430, ENSP00000450596, ENST00000542564, ENSP00000442493

HPA

ENSG00000187790-FANCM

GeneCards

FANCM

PRO

Q8IYD8

Pharos - Targets

Q8IYD8

Orphanet

FANCM

GlyGen

Q8IYD8

PDB

4E45, 4DRB, 4M6W, 4DAY, 4BXO

HMDB Protein

HMDBP11735

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTP7 FAAP24	2	FAAP24 [nucleoplasm] (R-HSA-419533) FAAP24 [cytosol] (R-HSA-420798)	0.811	13
UniProt:Q8N2Z9 CENPS	2	APITD1 [cytosol] (R-HSA-375310) APITD1 [nucleoplasm] (R-HSA-5633510)	0.641	4
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.539	5
UniProt:Q8NB91 FANCB	2	FANCB [cytosol] (R-HSA-420791) FANCB [nucleoplasm] (R-HSA-419528)	0.527	2
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.527	3
IntAct:EBI-12506732 SPLAYED			0.524	2

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