Reactome | MYH11 [cytosol]

MYH11 [cytosol]

Stable Identifier

R-HSA-420855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-11, MYH11_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH11 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH11 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH11 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35749 MYH11

Gene Names

MYH11, KIAA0866

Chain

chain:1-1972

Reference Genes

BioGPS Gene:4629 MYH11

COSMIC (genes):MYH11 MYH11

CTD Gene:4629 MYH11

dbSNP Gene:4629 MYH11

ENSEMBL:ENSG00000133392 MYH11

HGNC:7569 MYH11

KEGG:hsa:4629 MYH11

Monarch:4629 MYH11

NCBI Gene:4629 MYH11

OMIM:160745 MYH11

UCSC:P35749 MYH11

Reference Transcript

Other Identifiers

11732177_s_at

11732178_a_at

11732179_x_at

11762012_at

1568760_PM_at

1568760_at

16824258

201495_PM_x_at

201495_x_at

201496_PM_x_at

201496_x_at

201497_PM_x_at

201497_x_at

207961_PM_x_at

207961_x_at

228133_PM_s_at

228133_s_at

32582_at

3682027

3682029

3682030

3682031

3682032

3682034

3682035

3682037

3682038

3682039

3682040

3682041

3682042

3682043

3682044

3682045

3682046

3682047

3682048

3682049

3682050

3682051

3682052

3682054

3682055

3682057

3682062

3682066

3682067

3682068

3682069

3682070

3682071

3682072

3682074

3682075

3682076

3682077

3682078

3682079

3682080

3682081

3682082

3682083

3682084

3682086

3682091

3682092

3682094

3682099

3682102

3682103

3682107

3682109

3682110

3682111

3682112

3682113

3682118

3682122

3682129

3682131

3682132

37407_s_at

3959514

4629

767_at

773_at

774_g_at

77896_at

7999674

AF001548_rna1_at

A_23_P206920

A_24_P70183

D10667_s_at

GE81162

GO:0000146

GO:0003012

GO:0003774

GO:0003779

GO:0005198

GO:0005515

GO:0005516

GO:0005524

GO:0005737

GO:0005829

GO:0005859

GO:0006939

GO:0007010

GO:0008092

GO:0008307

GO:0016459

GO:0016460

GO:0030198

GO:0030241

GO:0031032

GO:0031410

GO:0032982

GO:0042470

GO:0043226

GO:0048251

GO:0048856

GO:0051015

GO:0055013

GO:0065003

GO:0070062

GO:0099512

GO:0140657

HMNXSV003058453

Hs.263925.2.S1_3p_at

Hs.78344.1.S1_3p_s_at

Hs.78344.1.S2_3p_a_at

Hs2.116881.1.A1_3p_at

ILMN_1660086

ILMN_2368834

PH_hs_0004518

PH_hs_0040938

TC16000898.hg

g13124874_3p_s_at

Participates

as a component of

as a member of

Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)

Inferred To

Homologues of MYH11 [cytosol] (Caenorhabditis elegans)

Homologues of MYH11 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYH11 [cytosol] (Schizosaccharomyces pombe)

MYH11 [cytosol] (Bos taurus)

MYH11 [cytosol] (Caenorhabditis elegans)

MYH11 [cytosol] (Canis familiaris)

MYH11 [cytosol] (Dictyostelium discoideum)

MYH11 [cytosol] (Drosophila melanogaster)

MYH11 [cytosol] (Gallus gallus)

MYH11 [cytosol] (Mus musculus)

MYH11 [cytosol] (Saccharomyces cerevisiae)

MYH11 [cytosol] (Schizosaccharomyces pombe)

MYH11 [cytosol] (Sus scrofa)

MYH11 [cytosol] (Xenopus tropicalis)

ZIP1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of MYH11 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_016878739.1, NP_001035202.1, NP_074035.1, NP_001035203.1, NP_002465.1

ENSEMBL

ENSP00000478816, ENSP00000478109, ENST00000300036, ENST00000634050, ENSP00000379616, ENSP00000407821, ENSP00000478092, ENST00000576790, ENST00000621545, ENST00000616422, ENSP00000300036, ENSP00000458731, ENSP00000488461, ENST00000396324, ENST00000452625, ENST00000612165

OpenTargets

ENSG00000133392

HPA

ENSG00000133392-MYH11

PRO

P35749

Pharos - Targets

P35749

GlyGen

P35749

Orphanet

MYH11

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	15