Endocytosis of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-421007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Endocytosis of Ca impermeable AMPA receptors
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GluR2 containing AMPA receptors are constitutively recycled between the endosome membrane and the plasma membrane. GRIP and PICK compete for the binding to the C tail of GluR2. Once the GluR2 containing AMPA receptors are in the plasmamembrane, phosphorylation of GluR2 at S880 by PKC causes disruption of GRIP interaction, but not PICK interaction which facilitates internalization of GluR2 containing AMPA receptors into endosomes.
Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Ziff, EB, Lu, W

Neuron 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium,diacylglycerol-dependent serine/threonine kinase activity of Activated conventional protein kinase C [plasma membrane]

Physical Entity
Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
Activity
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Orthologous Events
Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)
Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)
Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)
Endocytosis of Ca impermeable AMPA receptors (Mus musculus)
Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)
Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)
Authored
Mahajan, SS  (2008-01-14)
Reviewed
Ziff, EB  (2009-05-15)
Created
Mahajan, SS  (2009-05-15)
Cite Us!