Reactome | Cell-cell junction organization

Cell-cell junction organization

Stable Identifier

R-HSA-421270

DOI

10.3180/REACT_23419.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Epithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and composition. AJs play a critical role in initiating cell-cell contacts and promoting the maturation and maintenance of the contacts (reviewed in Ebnet, 2008; Hartsock and Nelson, 2008). TJs form physical barriers in various tissues and regulate paracellular transport of water, ions, and small water soluble molecules (reviewed in Rudini and Dejana, 2008; Ebnet, 2008; Aijaz et al., 2006; Furuse and Tsukit, 2006). Desmosomes mediate strong cell adhesion linking the intermediate filament cytoskeletons between cells and playing roles in wound repair, tissue morphogenesis, and cell signaling (reviewed in Holthofer et al., 2007).

Literature References

PubMed ID	Title	Journal	Year
16487793	Tight junctions: molecular architecture and function Matter, K, Balda, MS, Aijaz, S	Int Rev Cytol	2006
1616050	Structure, function, and regulation of cellular tight junctions Lynch, RD, Schneeberger, EE	Am J Physiol	1992
16537104	Claudins in occluding junctions of humans and flies Tsukita, S, Furuse, M	Trends Cell Biol	2006
19081036	Adherens junctions Rudini, N, Dejana, E	Curr Biol	2008
17854762	Adherens and tight junctions: structure, function and connections to the actin cytoskeleton Nelson, WJ, Hartsock, A	Biochim Biophys Acta	2008