Cleavage of the signal peptide of Preproghrelin

Stable Identifier
R-HSA-422051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of the signal peptide of Preproghrelin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The N-terminal 23 amino acid residues are cleaved from preproghrelin by the signal peptidase complex. The products are proghrelin (94 amino acid residues) or des-acyl-Gln14 proghrelin (93 amino acid residues), depending on the variant of the mRNA that was translated.
Literature References
PubMed ID Title Journal Year
19280057 Ghrelin fluctuation, what determines its production?

Yin, X, Li, Y, Zhang, W, An, W, Xu, G

Acta Biochim Biophys Sin (Shanghai) 2009
18396350 Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle

Soares, JB, Leite-Moreira, AF

Peptides 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Cleavage of the signal peptide of Preproghrelin (Bos taurus)
Cleavage of the signal peptide of Preproghrelin (Canis familiaris)
Cleavage of the signal peptide of Preproghrelin (Danio rerio)
Cleavage of the signal peptide of Preproghrelin (Gallus gallus)
Cleavage of the signal peptide of Preproghrelin (Mus musculus)
Cleavage of the signal peptide of Preproghrelin (Rattus norvegicus)
Cleavage of the signal peptide of Preproghrelin (Sus scrofa)
Authored
May, B  (2009-06-11)
Reviewed
Zhang, Weizhen  (2009-08-30)
Created
May, B  (2009-05-26)
Cite Us!