Heterotrimeric G(s) complex dissociates

Stable Identifier
R-HSA-422320
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Heterotrimeric G(s) complex dissociates
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The binding of GTP by G(s) alpha causes the heterotrimeric G-protein complex to reorientate, exposing previously bound faces of the G(s) alpha:GTP complex and the G-beta: G-gamma complex. Unlike the case with Gi/o heterotrimers, Gs heterotrimers are not observed to significantly dissociate in living cells.
Literature References
PubMed ID Title Journal Year
18577758 Dissociation of heterotrimeric g proteins in cells

Lambert, NA

Sci Signal 2008
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
17095603 Some G protein heterotrimers physically dissociate in living cells

Lambert, NA, Digby, GJ, Sethi, PR, Lober, RM

Proc Natl Acad Sci U S A 2006
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Morel, P, Widmann, C, Thorens, B, Porret, A, Buhler, L, Deng, SP

Diabetes 1993
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
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Output
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Catalyst Activity

G protein activity of G-alpha(s):GTP:G-beta:G-gamma [plasma membrane]

Physical Entity
G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
Activity
G protein activity (GO:0003925)
Authored
May, B  (2009-05-28)
Reviewed
Beitz, E  (2010-06-24)
Calamita, G  (2010-07-15)
D'Eustachio, P  (2024-01-29)
Created
May, B  (2009-05-28)
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