Reactome | SLC4A5,7,9 cotransport Na+ with 3HCO3-

SLC4A5,7,9 cotransport Na+ with 3HCO3-

Stable Identifier

R-HSA-425483

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Members of the SLC4A family couple the transport of bicarbonate (HCO3-) with sodium ions (Na+); they being members 4, 5, 7 and 9. SLC4A5 encodes a protein which is expressed in liver, spleen and testes, with lower levels expressed in parts of the brain and kidney (Sassani et al. 2002). It may have a housekeeping function in regulating the pH of these tissues (Pushkin et al. 2000).

SLC4A7 (aka NBC3, NBCn1) encodes a protein which performs electroneutral cotransport of Na+ and HCO3- with a 1:1 stoichiometry. It is highly expressed in testes and spleen and, to a lesser extent, in many other tissues including heart, muscle, kidney and GI tract (Pushkin et al. 1999).

SLC4A9 (aka AE4) was originally thought to exchange Cl- with HCO3- (hence the name AE4) but this has not been reported. Consensus has emerged that it is indeed a Na+/HCO3- co-transporter (Lipovich et al. 2001). It is predominantly expressed in the kidney, salivary glands, testes, thyroid glands and trachea (Parker et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11788353	Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter Sassani, P, Pushkin, A, Gross, E, Gomer, A, Abuladze, N, Dukkipati, R, Carpenito, G, Kurtz, I	Am J Physiol Cell Physiol	2002
10347222	Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family Pushkin, A, Abuladze, N, Lee, I, Newman, D, Hwang, J, Kurtz, I	J Biol Chem	1999
11305939	A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31 Lipovich, L, Lynch, ED, Lee, MK, King, MC	Genome Biol	2001
10978526	Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family Pushkin, A, Abuladze, N, Newman, D, Lee, I, Xu, G, Kurtz, I	Biochim Biophys Acta	2000
10362779	Characterization of Na+/HCO-3 cotransporter isoform NBC-3 Amlal, H, Burnham, CE, Soleimani, M	Am J Physiol	1999