Sodium/Calcium exchangers

Stable Identifier
R-HSA-425561
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Sodium/Calcium exchangers
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Calcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracellular compartments (Lytton J, 2007). They are the Na+/Ca2+ exchanger family designated NCX (SLC8) (three members NCX1-3) (Quednau BD et al, 2004), the Na+/Ca2+-K+ exchanger family designated NCKX (SLC24) (five members NCKX1-5) (Schnetkamp PP, 2004) and a Ca2+/cation exchanger (NCKX6, NCLX) whose physiological function remains unclear.
Literature References
PubMed ID Title Journal Year
17716241 Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport

Lytton, J

Biochem J 2007
14770312 The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond

Schnetkamp, PP

Pflugers Arch 2004
12734757 The sodium/calcium exchanger family-SLC8

Quednau, BD, Philipson, KD, Nicoll, DA

Pflugers Arch 2004
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as an event of
Orthologous Events
Sodium/Calcium exchangers (Bos taurus)
Sodium/Calcium exchangers (Caenorhabditis elegans)
Sodium/Calcium exchangers (Canis familiaris)
Sodium/Calcium exchangers (Danio rerio)
Sodium/Calcium exchangers (Drosophila melanogaster)
Sodium/Calcium exchangers (Gallus gallus)
Sodium/Calcium exchangers (Mus musculus)
Sodium/Calcium exchangers (Rattus norvegicus)
Sodium/Calcium exchangers (Saccharomyces cerevisiae)
Sodium/Calcium exchangers (Schizosaccharomyces pombe)
Sodium/Calcium exchangers (Sus scrofa)
Sodium/Calcium exchangers (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Jassal, B  (2009-06-05)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-06-05)
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