SLC9A6,7 exchange Na+ for H+ across the early endosome membrane

Stable Identifier
R-HSA-425983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
Na+/H+ exchanger transport (at early endosome membrane)
ReviewStatus
5/5
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SLC9A6,7 exchange Na+ for H+ across the early endosome membrane
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NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes.
Literature References
PubMed ID Title Journal Year
11940519 Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria

Brett, CL, Wei, Y, Rao, R, Donowitz, M

Am J Physiol Cell Physiol 2002
15522866 Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation

Mitsui, K, Tanaka, S, Teko, Y, Kanazawa, H, Nakamura, N

J Biol Chem 2005
Participants
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Output
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as an event of
Catalyst Activity

sodium:proton antiporter activity of SLC9A6,7 [early endosome membrane]

Physical Entity
SLC9A6,7 [early endosome membrane] (Homo sapiens)
Activity
sodium:proton antiporter activity (GO:0015385)
Orthologous Events
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Canis familiaris)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Danio rerio)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Dictyostelium discoideum)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Rattus norvegicus)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Saccharomyces cerevisiae)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Sus scrofa)
SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2009-06-11)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-06-11)
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