Reactome | Sodium/Proton exchangers

Sodium/Proton exchangers

Stable Identifier

R-HSA-425986

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.

Literature References

PubMed ID	Title	Journal	Year
11279194	Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network Orlowski, J, Numata, M	J Biol Chem	2001
12845533	Diversity of the mammalian sodium/proton exchanger SLC9 gene family Grinstein, S, Orlowski, J	Pflugers Arch	2004
15522866	Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation Mitsui, K, Tanaka, S, Teko, Y, Kanazawa, H, Nakamura, N	J Biol Chem	2005