Reactome | TRPC3(1-848) [plasma membrane]

TRPC3(1-848) [plasma membrane]

Stable Identifier

R-HSA-426172

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

TRPC3, Transient receptor potential channel 3, Short transient receptor potential channel 3, TRPC3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13507 TRPC3

Gene Names

TRPC3, TRP3

Chain

chain:1-921

Reference Genes

BioGPS Gene:7222 TRPC3

COSMIC (genes):TRPC3 TRPC3

CTD Gene:7222 TRPC3

dbSNP Gene:7222 TRPC3

ENSEMBL:ENSG00000138741 TRPC3

HGNC:12335 TRPC3

KEGG:hsa:7222 TRPC3

Monarch:7222 TRPC3

NCBI Gene:7222 TRPC3

OMIM:602345 TRPC3

UCSC:Q13507 TRPC3

Reference Transcript

Participates

as a member of

as an output of

TRPC3 gene transcription is stimulated by MECP2 (Homo sapiens)

Inferred To

TRPC3(1-848) [plasma membrane] (Gallus gallus)

TRPC3(1-848) [plasma membrane] (Mus musculus)

TRPC3(1-848) [plasma membrane] (Rattus norvegicus)

trpc3 [plasma membrane] (Xenopus tropicalis)

TRPC3 [plasma membrane] (Bos taurus)

TRPC3 [plasma membrane] (Canis familiaris)

TRPC3 [plasma membrane] (Sus scrofa)

trp-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

Guide to Pharmacology - Targets

488

ENSEMBL

ENSP00000368966, ENST00000379645, ENSP00000264811, ENST00000264811, ENSG00000138741

OpenTargets

ENSG00000138741

ZINC - Substances

TRPC3_HUMAN

ZINC target

Q13507

PRO

Q13507

GlyGen

Q13507

PDB

7DXE, 7DXD, 7DXB, 5ZBG, 6D7L, 7DXC, 6DJS, 6CUD

GeneCards

TRPC3

HPA

ENSG00000138741-TRPC3

Pharos - Targets

Q13507

Orphanet

TRPC3

ZINC - Predictions - Purchasable

TRPC3_HUMAN

HMDB Protein

HMDBP02622

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14573 ITPR3	2	ITPR3 [endoplasmic reticulum membrane] (R-HSA-169690) ITPR3 [platelet dense tubular network membrane] (R-HSA-418283)	0.591	5
UniProt:Q96D31 ORAI1	1	ORAI1 [plasma membrane] (R-HSA-434672)	0.544	2
UniProt:P20591 MX1	1	MX1 [cytosol] (R-HSA-947489)	0.524	2
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) PLCG1 [cytosol] (R-RNO-202320) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.508	2