Reactome | CBX3 [nucleoplasm]

CBX3 [nucleoplasm]

Stable Identifier

R-HSA-427386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HP1gamma, Chromobox protein homolog 3, CBX3_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13185 CBX3

Gene Names

CBX3

Chain

initiator methionine:1, chain:2-183

Reference Genes

BioGPS Gene:11335 CBX3

COSMIC (genes):CBX3 CBX3

CTD Gene:11335 CBX3

dbSNP Gene:11335 CBX3

ENSEMBL:ENSG00000122565 CBX3

ENSEMBL:ENSG00000122565.19 CBX3

HGNC:1553 CBX3

KEGG Gene (Homo sapiens):11335 CBX3

Monarch:11335 CBX3

NCBI Gene:11335 CBX3

OMIM:604477 CBX3

UCSC:Q13185 CBX3

Reference Transcript

Other Identifiers

11335

11715499_x_at

11754967_s_at

18670410

18670413

18670416

18670418

18670419

200037_PM_s_at

200037_s_at

201091_PM_s_at

201091_s_at

2971087

2993638

2993640

2993641

2993644

2993647

2993649

2993650

2993651

2993654

2993656

2993657

2993658

2993659

2993660

38084_at

38085_at

61813_at

73344_s_at

7892814

7893313

7893715

7894211

7894834

7894927

7895252

7895322

7895358

8131949

89994_r_at

A_23_P31315

GE53763

GO:0000122

GO:0000775

GO:0000779

GO:0000781

GO:0000785

GO:0000791

GO:0000792

GO:0001221

GO:0003682

GO:0005515

GO:0005634

GO:0005635

GO:0005637

GO:0005654

GO:0005694

GO:0005721

GO:0005819

GO:0005856

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006974

GO:0019899

GO:0019904

GO:0031507

GO:0035064

GO:0042393

GO:0042802

GO:0043226

GO:0045892

GO:0048511

GO:0061793

GO:0090575

GO:0090734

GO:1990226

HMNXSV003009753

HMNXSV003054584

Hs.278554.0.A1_3p_x_at

ILMN_1774086

ILMN_1782173

ILMN_1790625

PH_hs_0024337

TC07000160.hg

TC07002203.hg

U26312_s_at

g7705406_3p_s_at

Participates

as a component of

as an input of

Inferred To

HP1b [nucleoplasm] (Drosophila melanogaster)

cbx3 [nucleoplasm] (Danio rerio)

cbx3 [nucleoplasm] (Xenopus tropicalis)

CBX3 [nucleoplasm] (Bos taurus)

CBX3 [nucleoplasm] (Canis familiaris)

CBX3 [nucleoplasm] (Gallus gallus)

CBX3 [nucleoplasm] (Plasmodium falciparum)

CBX3 [nucleoplasm] (Sus scrofa)

swi6 [nucleoplasm] (Schizosaccharomyces pombe)

cec-3 [nucleoplasm] (Caenorhabditis elegans)

hcpC [nucleoplasm] (Dictyostelium discoideum)

Cbx3 [nucleoplasm] (Mus musculus)

Cbx3 [nucleoplasm] (Rattus norvegicus)

Homologues of CBX3 [nucleoplasm] (Dictyostelium discoideum)

hcpA [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_009207.2, NP_057671.2, XP_005249668.1

OpenTargets

ENSG00000122565

HPA

ENSG00000122565-CBX3

GeneCards

Q13185

Ensembl

ENSG00000122565, ENST00000337620, ENSP00000379670, ENSP00000336687, ENST00000396386

PRO

Q13185

Pharos - Targets

Q13185

PDB

2L11, 5T1I, 3TZD, 6HW2, 3DM1, 3KUP

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5T3J3 LRIF1			0.845	8
UniProt:Q13263 TRIM28	2	TRIM28 [nucleoplasm] (R-HSA-974998) SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600)	0.752	4
UniProt:Q6IQ32 ADNP2			0.75	5
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.742	8
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.725	5
UniProt:Q7Z3K3 POGZ			0.725	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.725	5
UniProt:Q96JM3 CHAP1			0.725	4
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.713	6
UniProt:Q9H2P0 ADNP			0.708	4
UniProt:Q9BWN1 PRR14			0.666	6
UniProt:Q8ND82 Z280C			0.666	4
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.659	3
UniProt:Q86Y97 KMT5C	1	KMT5C [nucleoplasm] (R-HSA-1183227)	0.656	3
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.643	3
UniProt:Q13111 CAF1A			0.643	3
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	4
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.643	4
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.643	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.641	3
UniProt:Q14739 LBR	4	LBR [endosome membrane] (R-HSA-9715094) LBR [endoplasmic reticulum membrane] (R-HSA-9714334) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811) LBR [nuclear envelope] (R-HSA-194637)	0.617	4
UniProt:Q9D752	1	Mad2l2 [nucleoplasm] (R-MMU-59092)	0.564	2
UniProt:Q9CY25	1	Mis12 [cytosol] (R-MMU-375313)	0.564	2
UniProt:P52815 MRPL12	1	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256)	0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P23497-2 SP100			0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q6N043-2 ZNF280D			0.556	3
UniProt:Q99988 GDF15			0.556	3
UniProt:P28838 AMPL			0.556	6
UniProt:Q6N043 Z280D			0.527	2
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.527	2
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.527	3
UniProt:Q8N9Z2 CC71L			0.527	2
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.527	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.527	3
UniProt:Q13112 CAF1B			0.527	3
UniProt:Q6P1K2 PMF1	1	PMF1 [cytosol] (R-HSA-375320)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.527	2
UniProt:Q9H582 ZN644			0.527	2
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.527	2
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.527	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.527	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	3
UniProt:Q5ZUS4 Q5ZUS4			0.508	2

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