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CBX3 [nucleoplasm]
Stable Identifier
R-HSA-427386
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HP1gamma, Chromobox protein homolog 3, CBX3_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9H9B1 EHMT1
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)
CBX3 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
CBX3 [nucleoplasm] (Homo sapiens)
E2F6 forms the PRC1L4 complex (Homo sapiens)
CBX3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13185 CBX3
Gene Names
CBX3
Chain
initiator methionine:, chain:2-183
Reference Genes
BioGPS Gene:11335 CBX3
COSMIC (genes):CBX3 CBX3
CTD Gene:11335 CBX3
dbSNP Gene:11335 CBX3
ENSEMBL:ENSG00000122565 CBX3
HGNC:1553 CBX3
KEGG:hsa:11335 CBX3
Monarch:11335 CBX3
NCBI Gene:11335 CBX3
OMIM:604477 CBX3
UCSC:Q13185 CBX3
Reference Transcript
RefSeq:NM_007276.4 CBX3
RefSeq:NM_016587.3 CBX3
RefSeq:XM_005249611.3 CBX3
Other Identifiers
11335
11715499_x_at
11754967_s_at
1555920_PM_at
1555920_at
16654801
16654803
16654805
16654809
16654811
16654813
16654815
16654821
16654823
16654825
17044423
18670410
18670411
18670412
18670413
18670414
18670415
18670416
18670417
18670418
18670419
200037_PM_s_at
200037_s_at
201091_PM_s_at
201091_s_at
230998_PM_at
230998_at
2971087
2993638
2993640
2993641
2993642
2993643
2993644
2993646
2993647
2993648
2993649
2993650
2993651
2993653
2993654
2993655
2993656
2993657
2993658
2993659
2993660
2993684
2993696
2993700
2993702
2993704
2993706
38084_at
38085_at
47980_at
54190_at
61813_at
73344_s_at
7892699
7892814
7893226
7893313
7893451
7893575
7893715
7893722
7894211
7894834
7894927
7895252
7895322
7895358
7895717
7896618
8131949
82714_at
89994_r_at
A_14_P119057
A_23_P31315
GE53763
GE84027
GO:0000122
GO:0000775
GO:0000779
GO:0000781
GO:0000785
GO:0000791
GO:0000792
GO:0001221
GO:0003682
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005654
GO:0005721
GO:0005819
GO:0006325
GO:0006338
GO:0006355
GO:0006974
GO:0019899
GO:0019904
GO:0031507
GO:0035064
GO:0042393
GO:0042802
GO:0043226
GO:0043229
GO:0045892
GO:0048511
GO:0061793
GO:0090575
GO:0090734
GO:1990226
HMNXSV003009753
HMNXSV003054584
Hs.145199.0.A1_3p_at
Hs.145199.0.A1_3p_x_at
Hs.278554.0.A1_3p_x_at
Hs2.411153.1.A1_3p_at
ILMN_1774086
ILMN_1782173
ILMN_1790625
PH_hs_0024337
TC07000160.hg
TC07002203.hg
U26312_s_at
g7705406_3p_s_at
Participates
as a component of
Chromatin (H3K9me2):CBX3 [nucleoplasm] (Homo sapiens)
PRC1L4 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
as an input of
CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)
E2F6 forms the PRC1L4 complex (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
Inferred To
HP1b [nucleoplasm]
(Drosophila melanogaster)
CBX3 [nucleoplasm]
(Bos taurus)
CBX3 [nucleoplasm]
(Canis familiaris)
CBX3 [nucleoplasm]
(Gallus gallus)
CBX3 [nucleoplasm]
(Plasmodium falciparum)
CBX3 [nucleoplasm]
(Sus scrofa)
swi6 [nucleoplasm]
(Schizosaccharomyces pombe)
hpl-1 [nucleoplasm]
(Caenorhabditis elegans)
hcpC [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of CBX3 [nucleoplasm]
(Saccharomyces cerevisiae)
Cbx3 [nucleoplasm]
(Mus musculus)
Cbx3 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000122565
ENSEMBL
ENST00000337620
,
ENSP00000379670
,
ENST00000396386
,
ENSP00000336687
HPA
ENSG00000122565-CBX3
PRO
Q13185
Pharos - Targets
Q13185
GlyGen
Q13185
PDB
5T1I
,
3KUP
,
3TZD
,
3DM1
,
2L11
,
6HW2
Interactors (62)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T3J3 LRIF1
0.882
9
UniProt:Q13263 TRIM28
3
TRIM28 [nucleoplasm]
(R-HSA-974998)
SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm]
(R-HSA-9842867)
SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm]
(R-HSA-3782600)
0.854
8
UniProt:Q9H2P0 ADNP
0.847
7
UniProt:Q6IQ32 ADNP2
0.806
6
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.8
9
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.788
7
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.788
6
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.788
6
UniProt:Q7Z3K3 POGZ
0.788
5
UniProt:Q96JM3 CHAP1
0.788
5
UniProt:Q8ND82 Z280C
0.742
5
UniProt:Q9BWN1 PRR14
0.742
7
UniProt:Q8IWI9 MGA
1
MGA [nucleoplasm]
(R-HSA-8953093)
0.738
4
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.725
5
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.725
5
UniProt:Q13111 CAF1A
0.725
4
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.713
6
UniProt:Q86Y97 KMT5C
1
KMT5C [nucleoplasm]
(R-HSA-1183227)
0.656
3
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.643
4
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.643
4
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.643
3
UniProt:Q9H582 ZN644
0.643
3
UniProt:Q96IY1 NSL1
1
NSL1 [cytosol]
(R-HSA-375309)
0.643
3
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.643
4
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.643
4
UniProt:Q8N9Z2 CC71L
0.643
3
UniProt:Q9H410 DSN1
3
DSN1 [cytosol]
(R-HSA-375308)
DSN1 [azurophil granule lumen]
(R-HSA-6799218)
DSN1 [extracellular region]
(R-HSA-6806228)
0.643
4
UniProt:Q9H081 MIS12
1
MIS12 [cytosol]
(R-HSA-375313)
0.643
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.641
3
UniProt:Q14739 LBR
4
LBR [nuclear envelope]
(R-HSA-194637)
p-S71,S86-LBR [nuclear envelope]
(R-HSA-9624811)
LBR [endoplasmic reticulum membrane]
(R-HSA-9714334)
LBR [endosome membrane]
(R-HSA-9715094)
0.617
4
UniProt:Q9D752
1
Mad2l2 [nucleoplasm]
(R-MMU-59092)
0.564
2
UniProt:Q9CY25
1
Mis12 [cytosol]
(R-MMU-375313)
0.564
2
UniProt:P28838 AMPL
0.556
6
UniProt:Q99988 GDF15
0.556
3
UniProt:Q6N043-2 ZNF280D
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:P23497-2 SP100
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9Y4B4 ARIP4
0.556
3
UniProt:P52815 MRPL12
2
MRPL12 [mitochondrial inner membrane]
(R-HSA-5368256)
MRPL12 [mitochondrial matrix]
(R-HSA-9839674)
0.556
3
UniProt:Q6N043 Z280D
0.527
2
UniProt:O95785 WIZ
0.527
2
UniProt:Q5TGY3 AHDC1
0.527
2
UniProt:Q9BQF6 SENP7
0.527
3
UniProt:Q6AHZ1 Z518A
0.527
3
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.527
3
UniProt:Q96JM2 ZN462
0.527
3
UniProt:P17098 ZNF8
0.527
2
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.527
2
UniProt:Q86XI8 ZSWM9
0.527
2
UniProt:Q8TDI0 CHD5
0.527
2
UniProt:Q13112 CAF1B
0.527
3
UniProt:Q9C0D4 Z518B
0.527
2
UniProt:Q6P1K2 PMF1
1
PMF1 [cytosol]
(R-HSA-375320)
0.527
2
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.527
2
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.527
2
UniProt:Q13129 RLF
0.527
2
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.527
3
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q5ZUS4 Q5ZUS4
0.508
2
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