Reactome | Me2K10-HIST2H3A [nucleoplasm]

Me2K10-HIST2H3A [nucleoplasm]

Stable Identifier

R-HSA-427407

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.2 with dimethylated lysine9 (H3K9)

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Maternal to zygotic transition (MZT) (Homo sapiens)
  - Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
    - DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)
      - Chromatin with DPPA3:H3K9me2 and 5mC [nucleoplasm] (Homo sapiens)
        
        Chromatin with H3K9me2, 5mC [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)
      - Chromatin with H3K9me2, 5mC [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Homo sapiens)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)
      - KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)
        
        MYC gene, BCL2 gene: H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG:KDM1A [nucleoplasm] (Homo sapiens)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)
      - Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)
        
        MYC gene, BCL2 gene: H3K9me2 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        MYC gene, BLC2 gene:H3K9me2, HIST1H2AC nucleosome:ESR1:ESTG [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me2 and HIST1H2AC: [nucleoplasm] (Homo sapiens)
        
        Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)
        
        Me2K10-HIST2H3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q71DI3 H3C15

Gene Names

H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D

Chain

chain:1-136

Reference Genes

BioGPS Gene:126961 H3C15

BioGPS Gene:333932 H3C15

BioGPS Gene:653604 H3C15

COSMIC (genes):HIST2H3A H3C15

COSMIC (genes):HIST2H3C H3C15

COSMIC (genes):HIST2H3D H3C15

CTD Gene:126961 H3C15

CTD Gene:333932 H3C15

CTD Gene:653604 H3C15

dbSNP Gene:126961 H3C15

dbSNP Gene:333932 H3C15

dbSNP Gene:653604 H3C15

ENSEMBL:ENSG00000183598 HIST2H3D

ENSEMBL:ENSG00000203811 HIST2H3C

ENSEMBL:ENSG00000203852 HIST2H3A

HGNC:20503 H3C15

HGNC:20505 H3C15

HGNC:25311 H3C15

KEGG:hsa:126961 H3C15

KEGG:hsa:333932 H3C15

KEGG:hsa:653604 H3C15

Monarch:126961 H3C15

Monarch:333932 H3C15

Monarch:653604 H3C15

NCBI Gene:126961 H3C15

NCBI Gene:333932 H3C15

NCBI Gene:653604 H3C15

OMIM:142780 H3C15

UCSC:Q71DI3 H3C15

Reference Transcript

Other Identifiers

11742410_s_at

126961

16670387

16692614

16692616

2357939

2357940

2434047

2434082

2434083

333932

653604

7905085

7919589

7919612

7919614

ADDON002755.hg

ADDON002789.hg

A_23_P115375

A_24_P324465

A_24_P45651

A_33_P3257678

GE79559

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

GO:0070062

HMNXSV003021896

HMNXSV003029395

ILMN_1664706

ILMN_1666179

PH_hs_0030802

PH_hs_0034534

TC01001175.hg

TC01003173.hg

TC01003188.hg

TC01003189.hg

Participates

as a candidate of

Me2K10-histone H3 [nucleoplasm] (Homo sapiens)

as a member of

Histone H3 dimethylated at lysine-9 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

2xAcK-HIST2H3A [nucleoplasm]

Me1K5-HIST2H3A [nucleoplasm]

Me2aR27-HIST2H3A [nucleoplasm]

Me2aR18-HIST2H3A [nucleoplasm]

Me2sR9-HIST2H3A [nucleoplasm]

Me2sR3-HIST2H3A [nucleoplasm]

AcK9,14-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]

AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]

AcK14,18-p-T11-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

Me2K28-HIST2H3A [nucleoplasm]

MeK37-HIST2H3A [nucleoplasm]

MeK80-HIST2H3A [nucleoplasm]

Me3K80-HIST2H3A [nucleoplasm]

Me2K80-HIST2H3A [nucleoplasm]

Me3K37-HIST2H3A [nucleoplasm]

Me2K37-HIST2H3A [nucleoplasm]

MeK-HIST2H3A [nucleoplasm]

MeK28-HIST2H3A [nucleoplasm]

MeK10-HIST2H3A [cytosol]

HIST2H3A [cytosol]

Me2aR3-HIST2H3A [nucleoplasm]

MeK5-HIST2H3A [nucleoplasm]

Cit27-HIST2H3A [nucleoplasm]

HIST2H3A [nucleoplasm]

Me2K5-HIST2H3A [nucleoplasm]

Me3K28-HIST2H3A [nucleoplasm]

Me3K10-HIST2H3A [nucleoplasm]

p-T12, Me3K-10-HIST2H3A [nucleoplasm]

p-T12, Me2K-10-HIST2H3A [nucleoplasm]

p-T12,MeK-HIST2H3A [nucleoplasm]

p-T12-HIST2H3A [nucleoplasm]

Me3K5-HIST2H3A [nucleoplasm]

AcK5-HIST2H3A [nucleoplasm]

AcK19-HIST2H3A [nucleoplasm]

Ack15-HIST2H3A [nucleoplasm]

AcK24-HIST2H3A [nucleoplasm]

HIST2H3A [extracellular region]

Ack10-HIST2H3A [nucleoplasm]

Me2K5,Me2aR3-HIST2H3A [nucleoplasm]

MeR9-HIST2H3A [nucleoplasm]

MeR27-HIST2H3A [nucleoplasm]

MeR3-HIST2H3A [nucleoplasm]

MeR18-HIST2H3A [nucleoplasm]

Cit18-HIST2H3A [nucleoplasm]

Cit9-HIST2H3A [nucleoplasm]

Cit3-HIST2H3A [nucleoplasm]

Inferred To

Homologues of Me2K10-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

cnp1 [nucleoplasm] (Schizosaccharomyces pombe)

H3a [nucleoplasm] (Dictyostelium discoideum)

His3:CG33845 [nucleoplasm] (Drosophila melanogaster)

Me2K10-HIST2H3A [nucleoplasm] (Bos taurus)

Me2K10-HIST2H3A [nucleoplasm] (Danio rerio)

CSE4 [nucleoplasm] (Saccharomyces cerevisiae)

Me2K10-Hist1h3b [nucleoplasm] (Mus musculus)

H3-VII [nucleoplasm] (Gallus gallus)

H3C14 [nucleoplasm] (Sus scrofa)

Me2K10-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

hcp-3 [nucleoplasm] (Caenorhabditis elegans)

Hist2h3c2 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

N6,N6-dimethyl-L-lysine at 10

Coordinate

PsiMod Name

N6,N6-dimethyl-L-lysine [MOD:00084]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.

Cross References

RefSeq

NP_066403.2, NP_001005464.1, NP_001116847.1

OpenTargets

ENSG00000203852, ENSG00000203811, ENSG00000183598

ENSEMBL

ENSP00000333277, ENSP00000385479, ENST00000403683, ENSP00000358154, ENST00000331491, ENST00000369158

HPA

ENSG00000203852-H3C15, ENSG00000183598-H3C13, ENSG00000203811-H3C14

PRO

Q71DI3

Pharos - Targets

Q71DI3

GlyGen

Q71DI3

PDB

3R93, 7BQZ, 6Y5E, 6T7C, 7PF2, 7PEZ, 7PF3, 8AAG, 6T7A, 7PEX, 6T79, 8AV6, 7PF0, 7PFF, 7PFA, 7PFC, 7PET, 7PEU, 7PEV, 4OUC, 7U53, 6X5A, 7U51, 7PFT, 7U50, 2X4X, 7JOA, 2IIJ, 8OL1, 4MZH, 8JLB, 5B0Y, 7PFV, 8JLD, 8ATF, 5BO0, 3AV1, 7BU9, 7XCR, 5VAC, 5CIU, 6Y5D, 7PEY, 6FML, 6T7D, 3QO2, 7JO9, 7PF4, 6T7B, 7JZV, 3MO8, 7PFD, 6ACE, 7PFE, 7PF6, 3DB3, 7PF5, 7PEW, 5B40, 7TAN, 8GRQ, 6XJD, 4MZF, 7U52, 6X59, 7PFX, 5B0Z, 2X4Y, 4MZG, 8HQY, 7YRD, 7PFU, 7XCT, 2X4W, 8HR1, 7XD0, 7PFW, 7UV9, 7UVA

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.704	4
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.576	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.576	5
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3