Reactome | eNoSC deacetylates histone H3

eNoSC deacetylates histone H3

Stable Identifier

R-HSA-427514

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The Sirtuin-1 (SIRT1) component of eNoSC deacetylates histone H3 at lysine-9 (Vaquero et al. 2004, Murayama et al. 2008). The reaction uses nicotinamide adenine dinucleotide (NAD) as the acceptor of the acetyl group and generates nicotinamide and 1-O-acetyl-ADP-ribose as products (Vaquero et al. 2004). The use of NAD links the reaction to the overall energy balance of the cell. Cells exposed to high glucose have a greater NADH:NAD ratio and therefore lower activity of eNoSC (Murayama et al. 2008). Low glucose produces higher NAD and higher activity of eNoSC.

Literature References

PubMed ID	Title	Journal	Year
18485871	Epigenetic control of rDNA loci in response to intracellular energy status Fujimura, A, Murayama, A, Minami, H, Nagata, K, Kuroda, T, Kimura, K, Oie, S, Ohmori, K, Yasuzawa-Tanaka, K, Daitoku, H, Yanagisawa, J, Fukamizu, A, Okuwaki, M, Shimizu, T	Cell	2008
15469825	Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin Scher, M, Reinberg, D, Lee, D, Tempst, P, Vaquero, A, Erdjument-Bromage, H	Mol. Cell	2004