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SUV39H1 [nucleoplasm]
Stable Identifier
R-HSA-427517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KMT1A, Histone-lysine N-methyltransferase SUV39H1, SUV91_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
SUV39H1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43463 SUV39H1
Gene Names
SUV39H1, KMT1A, SUV39H
Chain
chain:1-412
Reference Genes
BioGPS Gene:6839 SUV39H1
COSMIC (genes):SUV39H1 SUV39H1
CTD Gene:6839 SUV39H1
dbSNP Gene:6839 SUV39H1
ENSEMBL:ENSG00000101945 SUV39H1
ENSEMBL_homo_sapiens_GENE:ENSG00000101945.17 SUV39H1
HGNC:11479 SUV39H1
KEGG Gene (Homo sapiens):6839 SUV39H1
Monarch:6839 SUV39H1
NCBI Gene:6839 SUV39H1
OMIM:300254 SUV39H1
UCSC:O43463 SUV39H1
Reference Transcript
RefSeq:NM_001282166.1 SUV39H1
RefSeq:NM_003173.3 SUV39H1
Other Identifiers
11721277_a_at
11721278_s_at
11721279_x_at
11746768_a_at
11752693_a_at
17103413
218619_PM_s_at
218619_s_at
3976798
3976801
3976802
3976804
3976805
3976807
3976808
3976809
3976810
45149_at
6839
8167347
A_14_P137016
A_23_P422193
A_33_P3407524
GE58298
GO:0000122
GO:0000183
GO:0000228
GO:0000775
GO:0000792
GO:0000794
GO:0000976
GO:0003677
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005652
GO:0005654
GO:0005677
GO:0005694
GO:0005730
GO:0005886
GO:0006325
GO:0006351
GO:0006355
GO:0006364
GO:0006974
GO:0007049
GO:0007623
GO:0008168
GO:0008270
GO:0008757
GO:0016020
GO:0016740
GO:0030154
GO:0031065
GO:0031410
GO:0032259
GO:0033553
GO:0034968
GO:0036211
GO:0042054
GO:0042149
GO:0042254
GO:0043226
GO:0044725
GO:0045786
GO:0045892
GO:0046015
GO:0046872
GO:0046974
GO:0048511
GO:0048856
GO:0061773
GO:0071456
GO:0097009
GO:0140096
GO:0140938
GO:0140949
HMNXSV003055733
ILMN_1781479
PH_hs_0002968
TC0X000258.hg
g4507320_3p_s_at
Participates
as an input of
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
as a component of
eNoSC [nucleoplasm] (Homo sapiens)
as a member of
SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of SUV39H1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of SUV39H1 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of SUV39H1 [nucleoplasm]
(Schizosaccharomyces pombe)
SUV39H1 [nucleoplasm]
(Bos taurus)
SUV39H1 [nucleoplasm]
(Canis familiaris)
SUV39H1 [nucleoplasm]
(Drosophila melanogaster)
SUV39H1 [nucleoplasm]
(Mus musculus)
SUV39H1 [nucleoplasm]
(Rattus norvegicus)
SUV39H1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001269095.1
,
NP_003164.1
ZINC - World Drugs
SUV91_HUMAN
Guide to Pharmacology - Targets
2715
OpenTargets
ENSG00000101945
ZINC - Substances
SUV91_HUMAN
ZINC target
O43463
ZINC - Biogenic
SUV91_HUMAN
PRO
O43463
PDB
3MTS
ZINC - Metabolites
SUV91_HUMAN
IntEnz
2.1.1.355
HPA
ENSG00000101945-SUV39H1
GeneCards
O43463
Ensembl
ENSP00000337976
,
ENSG00000101945
,
ENST00000376687
,
ENSP00000365877
,
ENST00000337852
Pharos - Targets
O43463
ZINC - Predictions - Purchasable
SUV91_HUMAN
HMDB Protein
HMDBP00422
Interactors (65)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.949
18
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.8
9
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.742
6
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.718
6
UniProt:Q9BRK4 LZTS2
0.718
6
UniProt:Q96ED9 HOOK2
0.666
4
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q9C0K0 BC11B
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:Q96I34 PP16A
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q6TGC4 PADI6
2
PADI6 [cytosol]
(R-HSA-1183183)
PADI6 [nucleoplasm]
(R-HSA-6793449)
0.556
3
IntAct:EBI-25911596 CCSB
0.556
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q8N680 ZBTB2
0.556
3
UniProt:V9HWG0 V9HWG0
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.556
3
UniProt:Q86V38 Q86V38
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q7Z4V0 ZN438
0.556
3
UniProt:Q9UIS9 MBD1
2
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
MBD1 [nucleoplasm]
(R-HSA-417134)
0.556
5
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.544
5
UniProt:Q9UPU5 USP24
1
USP24 [nucleoplasm]
(R-HSA-5697004)
0.527
2
UniProt:O60732 MAGC1
0.527
2
UniProt:Q15018 FAM175B
1
FAM175B [cytosol]
(R-HSA-5691428)
0.527
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.527
2
UniProt:Q9NPA3 MID1IP1
1
MID1IP1 [cytosol]
(R-HSA-8867328)
0.527
2
UniProt:Q15156 Q15156
0.524
4
UniProt:O43159 RRP8
1
RRP8 [nucleoplasm]
(R-HSA-427524)
0.524
3
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.524
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.524
3
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.508
2
UniProt:O95260 ATE1
0.508
2
UniProt:Q9NS23 RASF1
0.508
2
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.508
2
UniProt:Q01081 U2AF1
1
U2AF1 [nucleoplasm]
(R-HSA-71985)
0.508
2
UniProt:P49761 CLK3
0.508
2
UniProt:Q6ZNL6 FGD5
1
FGD5 [cytosol]
(R-HSA-9714447)
0.508
2
UniProt:Q9C0F3 ZNF436
1
ZNF436 [nucleoplasm]
(R-HSA-1247538)
0.508
2
UniProt:Q5TAQ9 DCAF8
1
DCAF8 [nucleoplasm]
(R-HSA-8955192)
0.508
2
UniProt:Q9BXL8 CDCA4
0.508
2
UniProt:Q9BS31 ZNF649
1
ZNF649 [nucleoplasm]
(R-HSA-2127585)
0.508
2
UniProt:Q9BS34 ZNF670
1
ZNF670 [nucleoplasm]
(R-HSA-2248887)
0.508
2
UniProt:Q6P047 CH074
0.508
2
UniProt:Q8N4C7 STX19
0.508
2
UniProt:Q9NWQ4 GPT2L
0.508
2
UniProt:Q9BX10 GTPBP2
2
GTPBP2 [extracellular region]
(R-HSA-8863001)
GTPBP2 [platelet alpha granule lumen]
(R-HSA-8862960)
0.508
2
UniProt:A5D8V7 ODAD3
0.508
2
UniProt:Q8TBB5 KLDC4
0.508
2
UniProt:P50749 RASF2
0.508
2
UniProt:Q9Y2L8 ZKSCAN5
1
ZKSCAN5 [nucleoplasm]
(R-HSA-975021)
0.508
2
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.508
2
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.508
2
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.508
2
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.508
2
UniProt:Q13133 NR1H3
1
NR1H3 [nucleoplasm]
(R-HSA-8854957)
0.508
2
UniProt:Q9H9B1-1 EHMT1
0.462
2
UniProt:Q96KQ7-1 EHMT2
0.462
2
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