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RRP8 [nucleoplasm]
Stable Identifier
R-HSA-427524
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NML, Nucleomethylin, Cerebral protein 1, KIAA0409, HUCE1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
RRP8 binds RNA (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
RRP8:5S RNA, rRNA [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC deacetylates histone H3 (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43159 RRP8
Gene Names
RRP8, KIAA0409, NML, hucep-1
Chain
chain:1-456
Reference Genes
BioGPS Gene:23378 RRP8
COSMIC (genes):RRP8 RRP8
CTD Gene:23378 RRP8
dbSNP Gene:23378 RRP8
ENSEMBL:ENSG00000132275 RRP8
HGNC:29030 RRP8
KEGG Gene (Homo sapiens):23378 RRP8
Monarch:23378 RRP8
NCBI Gene:23378 RRP8
OMIM:615818 RRP8
UCSC:O43159 RRP8
Reference Transcript
RefSeq:NM_015324.3 RRP8
Other Identifiers
0004730022
11727057_a_at
11756354_a_at
16735121
203170_at
203171_s_at
23378
3360998
3360999
3361000
3361001
3361002
3361003
3361004
3361005
3361006
3361007
3361008
3361010
3361011
3361012
3361014
3361015
3361016
3361018
3361019
36087_at
61240_at
7946211
A_23_P356565
GE81997
GO:0000183
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0006364
GO:0006950
GO:0007049
GO:0007165
GO:0008150
GO:0008168
GO:0008219
GO:0008757
GO:0009058
GO:0016740
GO:0022607
GO:0032259
GO:0032991
GO:0033553
GO:0034641
GO:0035064
GO:0042149
GO:0042254
GO:0042393
GO:0043226
GO:0046015
GO:0051276
GO:0071158
GO:0072332
HMNXSV003023648
Hs.5158.0.S2_3p_at
Hs.5158.0.S2_3p_x_at
ILMN_1765272
ILMN_2066667
PH_hs_0026683
TC11003503.hg
g12758124_3p_a_at
Participates
as a component of
RRP8:5S RNA, rRNA [nucleoplasm] (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
as an input of
RRP8 binds RNA (Homo sapiens)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
Inferred To
Ghost homologue of RRP8 [nucleoplasm]
(Danio rerio)
RRP8 [nucleoplasm]
(Bos taurus)
RRP8 [nucleoplasm]
(Caenorhabditis elegans)
RRP8 [nucleoplasm]
(Canis familiaris)
RRP8 [nucleoplasm]
(Drosophila melanogaster)
RRP8 [nucleoplasm]
(Plasmodium falciparum)
RRP8 [nucleoplasm]
(Saccharomyces cerevisiae)
RRP8 [nucleoplasm]
(Sus scrofa)
rrp8 [nucleoplasm]
(Dictyostelium discoideum)
rrp8 [nucleoplasm]
(Schizosaccharomyces pombe)
Rrp8 [nucleoplasm]
(Mus musculus)
Rrp8 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_056139.1
OpenTargets
ENSG00000132275
GeneCards
O43159
HPA
ENSG00000132275-RRP8
Ensembl
ENSP00000254605
,
ENST00000254605
,
ENSG00000132275
PRO
O43159
Pharos - Targets
O43159
GlyGen
O43159
PDB
2ZFU
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.524
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.524
3
IntAct:EBI-1177816 H3
0.499
4
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