Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RRP8 [nucleoplasm]
Stable Identifier
R-HSA-427524
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NML, Nucleomethylin, Cerebral protein 1, KIAA0409, HUCE1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
RRP8 binds RNA (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
RRP8:5S RNA, rRNA [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC deacetylates histone H3 (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
RRP8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43159 RRP8
Gene Names
RRP8, KIAA0409, NML, hucep-1
Chain
chain:1-456
Reference Genes
BioGPS Gene:23378 RRP8
COSMIC (genes):RRP8 RRP8
CTD Gene:23378 RRP8
dbSNP Gene:23378 RRP8
ENSEMBL:ENSG00000132275 RRP8
ENSEMBL_homo_sapiens_GENE:ENSG00000132275.11 RRP8
HGNC:29030 RRP8
KEGG Gene (Homo sapiens):23378 RRP8
Monarch:23378 RRP8
NCBI Gene:23378 RRP8
OMIM:615818 RRP8
UCSC:O43159 RRP8
Reference Transcript
RefSeq:NM_015324.3 RRP8
Other Identifiers
11727057_a_at
11756354_a_at
16735121
203170_PM_at
203170_at
203171_PM_s_at
203171_s_at
23378
3360998
3360999
3361000
3361001
3361002
3361003
3361004
3361005
3361006
3361007
3361008
3361010
3361011
3361012
3361014
3361015
3361016
3361018
3361019
36087_at
61240_at
7946211
A_23_P356565
GE81997
GO:0000183
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005730
GO:0005829
GO:0005886
GO:0006325
GO:0006351
GO:0006355
GO:0006364
GO:0008168
GO:0008757
GO:0012501
GO:0016740
GO:0023052
GO:0031062
GO:0031065
GO:0032259
GO:0033553
GO:0035064
GO:0036211
GO:0042149
GO:0042254
GO:0042393
GO:0043226
GO:0045786
GO:0045892
GO:0046015
GO:0061773
GO:0072332
GO:0097009
GO:1903450
HMNXSV003023648
Hs.5158.0.S2_3p_at
Hs.5158.0.S2_3p_x_at
ILMN_2066667
PH_hs_0026683
TC11003503.hg
g12758124_3p_a_at
Participates
as a component of
RRP8:5S RNA, rRNA [nucleoplasm] (Homo sapiens)
eNoSC [nucleoplasm] (Homo sapiens)
as an input of
RRP8 binds RNA (Homo sapiens)
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Homo sapiens)
Inferred To
RRP8 [nucleoplasm]
(Bos taurus)
RRP8 [nucleoplasm]
(Caenorhabditis elegans)
RRP8 [nucleoplasm]
(Canis familiaris)
RRP8 [nucleoplasm]
(Dictyostelium discoideum)
RRP8 [nucleoplasm]
(Drosophila melanogaster)
RRP8 [nucleoplasm]
(Mus musculus)
RRP8 [nucleoplasm]
(Plasmodium falciparum)
RRP8 [nucleoplasm]
(Rattus norvegicus)
RRP8 [nucleoplasm]
(Saccharomyces cerevisiae)
RRP8 [nucleoplasm]
(Schizosaccharomyces pombe)
RRP8 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_056139.1
OpenTargets
ENSG00000132275
HPA
ENSG00000132275-RRP8
GeneCards
O43159
Ensembl
ENSP00000254605
,
ENST00000254605
,
ENSG00000132275
PRO
O43159
Pharos - Targets
O43159
PDB
2ZFU
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.524
3
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.524
3
IntAct:EBI-1177816 H3
0.499
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text