Reactome | RRP8 [nucleoplasm]

RRP8 [nucleoplasm]

Stable Identifier

R-HSA-427524

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

NML, Nucleomethylin, Cerebral protein 1, KIAA0409, HUCE1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9UII4 HERC5

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External Reference Information

External Reference

UniProt:O43159 RRP8

Gene Names

RRP8, KIAA0409, NML, hucep-1

Chain

chain:1-456

Reference Genes

BioGPS Gene:23378 RRP8

COSMIC (genes):RRP8 RRP8

CTD Gene:23378 RRP8

dbSNP Gene:23378 RRP8

ENSEMBL:ENSG00000132275 RRP8

ENSEMBL_homo_sapiens_GENE:ENSG00000132275.11 RRP8

HGNC:29030 RRP8

KEGG Gene (Homo sapiens):23378 RRP8

Monarch:23378 RRP8

NCBI Gene:23378 RRP8

OMIM:615818 RRP8

UCSC:O43159 RRP8

Reference Transcript

RefSeq:NM_015324.3 RRP8

Other Identifiers

11727057_a_at

11756354_a_at

16735121

203170_PM_at

203170_at

203171_PM_s_at

203171_s_at

23378

3360998

3360999

3361000

3361001

3361002

3361003

3361004

3361005

3361006

3361007

3361008

3361010

3361011

3361012

3361014

3361015

3361016

3361018

3361019

36087_at

61240_at

7946211

A_23_P356565

GE81997

GO:0000183

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005677

GO:0005694

GO:0005730

GO:0005829

GO:0005886

GO:0006325

GO:0006351

GO:0006355

GO:0006364

GO:0008168

GO:0008757

GO:0012501

GO:0016740

GO:0023052

GO:0031065

GO:0032259

GO:0033553

GO:0035064

GO:0036211

GO:0042149

GO:0042254

GO:0042393

GO:0043226

GO:0045786

GO:0045892

GO:0046015

GO:0061773

GO:0072332

GO:0097009

GO:1903450

HMNXSV003023648

Hs.5158.0.S2_3p_at

Hs.5158.0.S2_3p_x_at

ILMN_2066667

PH_hs_0026683

TC11003503.hg

g12758124_3p_a_at

Participates

as a component of

as an input of

Inferred To

RRP8 [nucleoplasm] (Bos taurus)

RRP8 [nucleoplasm] (Caenorhabditis elegans)

RRP8 [nucleoplasm] (Canis familiaris)

RRP8 [nucleoplasm] (Dictyostelium discoideum)

RRP8 [nucleoplasm] (Drosophila melanogaster)

RRP8 [nucleoplasm] (Mus musculus)

RRP8 [nucleoplasm] (Plasmodium falciparum)

RRP8 [nucleoplasm] (Rattus norvegicus)

RRP8 [nucleoplasm] (Saccharomyces cerevisiae)

RRP8 [nucleoplasm] (Schizosaccharomyces pombe)

RRP8 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_056139.1

OpenTargets

ENSG00000132275

HPA

ENSG00000132275-RRP8

GeneCards

O43159

Ensembl

ENST00000254605, ENSP00000254605, ENSG00000132275

PRO

O43159

Pharos - Targets

O43159

PDB

2ZFU

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.615	4
UniProt:Q2TB10 ZN800			0.615	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q8N8A6 DDX51			0.527	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	4
UniProt:P42696 RBM34			0.527	4
UniProt:Q9NZM5 NOP53			0.527	4
UniProt:P51608 MECP2			0.527	3
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q99676 ZNF184	1	ZNF184 [nucleoplasm] (R-HSA-974987)	0.527	3
UniProt:Q9BXY0 MAK16			0.527	2
UniProt:Q9GZR2 REXO4			0.527	3
UniProt:Q8N5C6 SRBD1			0.527	2
UniProt:Q96K58 ZNF668	1	ZNF668 [nucleoplasm] (R-HSA-2248872)	0.527	2
UniProt:Q68D10 SPT2			0.527	3
UniProt:Q8NB50 ZFP62			0.527	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q14146 URB2			0.527	2
UniProt:Q9UNX4 WDR3	1	WDR3 [nucleoplasm] (R-HSA-6790724)	0.527	3
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.527	2
UniProt:Q9BWF3 RBM4	1	RBM4 [cytosol] (R-HSA-8878898)	0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	3
UniProt:Q9BZE4 GTPB4			0.527	4
UniProt:Q5VWQ0 RSBN1			0.527	2
UniProt:Q02539 H1-1	1	HIST1H1A [nucleoplasm] (R-HSA-211245)	0.527	3
UniProt:Q03701 CEBPZ			0.527	3
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.527	2
UniProt:Q9P0M6 H2AW			0.527	2
UniProt:O15381 NVL			0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	3
UniProt:Q96MX3 ZNF48			0.527	3
UniProt:Q9H8H2 DDX31			0.527	4
UniProt:Q9BSG1 ZNF2	1	ZNF2 [nucleoplasm] (R-HSA-975031)	0.527	2
UniProt:Q9H7N4 SFR19			0.527	2
UniProt:Q9GZR7 DDX24			0.527	4
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	3
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.527	3
UniProt:Q96HE9 PRR11			0.527	2
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
UniProt:Q9H7B2 RPF2			0.527	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.527	3
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.527	3
UniProt:Q02543 RPL18A	1	RPL18A [cytosol] (R-HSA-72422)	0.527	3
UniProt:Q9BQ39 DDX50			0.527	2
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611)	0.527	2
UniProt:Q5JTH9 RRP12			0.527	4
UniProt:Q9H9Y2 RPF1			0.527	2
UniProt:P62910 RPL32	1	RPL32 [cytosol] (R-HSA-72456)	0.527	3
UniProt:Q15397 PUM3			0.527	4
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.527	2
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	3
UniProt:O60287 NPA1P			0.527	3
UniProt:Q96ME7 ZN512			0.527	2
UniProt:Q9NQ55 SSF1			0.527	2
UniProt:P51114 FXR1	2	FXR1(2-784)-BRAF(381-766) fusion [cytosol] (R-HSA-6802326) FXR1(2-784)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802530)	0.527	2
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.527	2
UniProt:Q9UII4 HERC5	1	HERC5 [cytosol] (R-HSA-936553)	0.527	2
UniProt:Q96GQ7 DDX27			0.527	3
UniProt:Q8TDN6 BRX1			0.527	3
UniProt:Q6PK04 CC137			0.527	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.524	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
IntAct:EBI-1177816 H3			0.499	4
UniProt:Q9Y2R4 DDX52	1	DDX52 [nucleoplasm] (R-HSA-6790703)	0.483	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	3
UniProt:Q6ZN17 LN28B			0.483	2
UniProt:P51116 FXR2			0.483	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.483	3
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	3

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