SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol

Stable Identifier
R-HSA-427555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol
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The SLC26A1 and 2 genes encode proteins that facilitate sulfate (SO4(2-)) uptake into cells (Alper & Sharma 2013). The mechanism by which these transporters work is unclear but may be enhanced by extracellular halides or acidic pH environments, cotransporting protons electroneutrally. Both can transport SO4(2-) (as well as oxalate and Cl-) across the basolateral membrane of epithelial cells. SLC26A1 encodes the sulfate anion transporter 1 (SAT1) (Regeer et al. 2003) and is most abundantly expressed in the liver and kidney, with lower levels expressed in many other parts of the body. SLC26A2 is ubiquitously expressed and encodes a sulfate transporter (Diastrophic dysplasia protein, DTD, DTDST) (Hastbacka et al. 1994). This transporter provides sulfate for sulfation of glycosaminoglycan chains in proteoglycans needed for cartilage development. Defects in SLC26A2 are implicated in the pathogenesis of several human chondrodysplasias.
Literature References
PubMed ID Title Journal Year
12713736 Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)

Regeer, RR, Markovich, D, Lee, A

DNA Cell Biol 2003
23506885 The SLC26 gene family of anion transporters and channels

Alper, SL, Sharma, AK

Mol. Aspects Med. 2013
7923357 The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping

Reeve-Daly, MP, Clines, G, Weaver, A, Mahtani, MM, Kusumi, K, Daly, M, Trivedi, B, Hamilton, BA, de la Chapelle, A

Cell 1994
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
sulfate transmembrane transport (1902358)
Catalyst Activity

sulfate transmembrane transporter activity of SLC26A1,2 [plasma membrane]

Physical Entity
SLC26A1,2 [plasma membrane] (Homo sapiens)
Activity
sulfate transmembrane transporter activity (GO:0015116)
Orthologous Events
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Bos taurus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Drosophila melanogaster)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Gallus gallus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Mus musculus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Schizosaccharomyces pombe)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)
SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)
Authored
Jassal, B  (2009-06-23)
Reviewed
Hill, DP  (2022-05-19)
Created
Jassal, B  (2009-06-23)
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