Reactome | SLC26A3,6 exchange Cl- for HCO3-

SLC26A3,6 exchange Cl- for HCO3-

Stable Identifier

R-HSA-427666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Group 2 - Cl-/HCO3- exchanger transport

ReviewStatus

5/5

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The proteins responsible for the exchange of chloride (Cl-) with bicarbonate (HCO3-) are members of the SLC4 (1-3) and SLC26 (3 and 6) transporter families. SLC4 members are discussed in the section "Bicarbonate transporters".

SLC26A3 (Chloride anion exchanger, Down-regulated in adenoma, DRA) is expressed in the mucosa of the colon and helps mediate electrolyte and fluid absorption (Schweinfest et al. 1993). Defects in SLC26A3 cause congenital chloride diarrhea 1 (DIAR1), a disease characterized by watery stools containing an excess of chloride (Hoeglund et al. 1996). SLC26A6 encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate (Waldegger et al. 2001). It is ubiquitously expressed, the highest levels present in kidney and pancreas.

Literature References

PubMed ID	Title	Journal	Year
7683425	Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas Papas, TS, Schweinfest, CW, Suster, S, Kondoh, N, Henderson, KW	Proc Natl Acad Sci U S A	1993
11247665	Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family Ramirez, A, Waldegger, S, Ayadi, H, Lang, F, Smith, RJ, Kubisch, C, Moschen, I	Genomics	2001
11834742	Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9 Makela, S, Kestila, M, Markovich, D, Kere, J, Saarialho-Kere, U, Lehtonen, E, Kujala, M, Lohi, H	J Biol Chem	2002
8896562	Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea Tomaszewski, L, Holmberg, C, Socha, J, Höglund, P, Haila, S, Airola, K, Karjalainen-Lindsberg, ML, Kere, J, de la Chapelle, A, Saarialho-Kere, U	Nat Genet	1996