Reactome | Me3K10-HIST2H3A [nucleoplasm]

Me3K10-HIST2H3A [nucleoplasm]

Stable Identifier

R-HSA-427744

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.2 with trimethylated lysine9 (H3K9)

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)
      - KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Homo sapiens)
        
        KDM4B-regulated genes:H3K9me3 nucleosome:ESR1:ESTG:KDM4B [nucleoplasm] (Homo sapiens)
        
        KDM4B-regulated genes:H3K9me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Homo sapiens)
        
        H3K9me3 [nucleoplasm] (Homo sapiens)
        
        Me3K10-HIST2H3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q71DI3 H3C15

Gene Names

H3C15, HIST2H3A, H3C14, H3F2, H3FM, HIST2H3C, H3C13, HIST2H3D

Chain

chain:1-136

Reference Genes

BioGPS Gene:126961 H3C15

BioGPS Gene:333932 H3C15

BioGPS Gene:653604 H3C15

COSMIC (genes):HIST2H3A H3C15

COSMIC (genes):HIST2H3C H3C15

COSMIC (genes):HIST2H3D H3C15

CTD Gene:126961 H3C15

CTD Gene:333932 H3C15

CTD Gene:653604 H3C15

dbSNP Gene:126961 H3C15

dbSNP Gene:333932 H3C15

dbSNP Gene:653604 H3C15

ENSEMBL:ENSG00000183598 HIST2H3D

ENSEMBL:ENSG00000203811 HIST2H3C

ENSEMBL:ENSG00000203852 HIST2H3A

HGNC:20503 H3C15

HGNC:20505 H3C15

HGNC:25311 H3C15

KEGG:hsa:126961 H3C15

KEGG:hsa:333932 H3C15

KEGG:hsa:653604 H3C15

Monarch:126961 H3C15

Monarch:333932 H3C15

Monarch:653604 H3C15

NCBI Gene:126961 H3C15

NCBI Gene:333932 H3C15

NCBI Gene:653604 H3C15

OMIM:142780 H3C15

UCSC:Q71DI3 H3C15

Reference Transcript

Other Identifiers

11742410_s_at

126961

16670387

16692614

16692616

2357939

2357940

2434047

2434082

2434083

333932

653604

7905085

7919589

7919612

7919614

ADDON002755.hg

ADDON002789.hg

A_23_P115375

A_24_P324465

A_24_P45651

A_33_P3257678

GE79559

GO:0000786

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0030527

GO:0043226

GO:0043229

GO:0046982

GO:0065003

GO:0070062

HMNXSV003021896

HMNXSV003029395

ILMN_1664706

ILMN_1666179

PH_hs_0030802

PH_hs_0034534

TC01001175.hg

TC01003173.hg

TC01003188.hg

TC01003189.hg

Participates

as a candidate of

Me3K10-histone H3 [nucleoplasm] (Homo sapiens)

as a member of

H3K9me3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

2xAcK-HIST2H3A [nucleoplasm]

Me1K5-HIST2H3A [nucleoplasm]

Me2aR27-HIST2H3A [nucleoplasm]

Me2aR18-HIST2H3A [nucleoplasm]

Me2sR9-HIST2H3A [nucleoplasm]

Me2sR3-HIST2H3A [nucleoplasm]

AcK9,14-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]

AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]

AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

AcK14,18-p-S10-HIST2H3A [nucleoplasm]

AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]

AcK14,18-p-T11-HIST2H3A [nucleoplasm]

AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]

Me2K28-HIST2H3A [nucleoplasm]

MeK37-HIST2H3A [nucleoplasm]

MeK80-HIST2H3A [nucleoplasm]

Me3K80-HIST2H3A [nucleoplasm]

Me2K80-HIST2H3A [nucleoplasm]

Me3K37-HIST2H3A [nucleoplasm]

Me2K37-HIST2H3A [nucleoplasm]

MeK-HIST2H3A [nucleoplasm]

MeK28-HIST2H3A [nucleoplasm]

MeK10-HIST2H3A [cytosol]

HIST2H3A [cytosol]

Me2aR3-HIST2H3A [nucleoplasm]

MeK5-HIST2H3A [nucleoplasm]

Cit27-HIST2H3A [nucleoplasm]

HIST2H3A [nucleoplasm]

Me2K5-HIST2H3A [nucleoplasm]

Me3K28-HIST2H3A [nucleoplasm]

p-T12, Me3K-10-HIST2H3A [nucleoplasm]

p-T12, Me2K-10-HIST2H3A [nucleoplasm]

p-T12,MeK-HIST2H3A [nucleoplasm]

p-T12-HIST2H3A [nucleoplasm]

Me2K10-HIST2H3A [nucleoplasm]

Me3K5-HIST2H3A [nucleoplasm]

AcK5-HIST2H3A [nucleoplasm]

AcK19-HIST2H3A [nucleoplasm]

Ack15-HIST2H3A [nucleoplasm]

AcK24-HIST2H3A [nucleoplasm]

HIST2H3A [extracellular region]

Ack10-HIST2H3A [nucleoplasm]

Me2K5,Me2aR3-HIST2H3A [nucleoplasm]

MeR9-HIST2H3A [nucleoplasm]

MeR27-HIST2H3A [nucleoplasm]

MeR3-HIST2H3A [nucleoplasm]

MeR18-HIST2H3A [nucleoplasm]

Cit18-HIST2H3A [nucleoplasm]

Cit9-HIST2H3A [nucleoplasm]

Cit3-HIST2H3A [nucleoplasm]

Inferred To

cnp1 [nucleoplasm] (Schizosaccharomyces pombe)

Me3K10-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

H3a [nucleoplasm] (Dictyostelium discoideum)

His3:CG33845 [nucleoplasm] (Drosophila melanogaster)

Me3K10-HIST2H3A [nucleoplasm] (Bos taurus)

Me3K10-HIST2H3A [nucleoplasm] (Danio rerio)

CSE4 [nucleoplasm] (Saccharomyces cerevisiae)

Me3K10-Hist1h3b [nucleoplasm] (Mus musculus)

H3-VII [nucleoplasm] (Gallus gallus)

H3C14 [nucleoplasm] (Sus scrofa)

hcp-3 [nucleoplasm] (Caenorhabditis elegans)

Hist2h3c2 [nucleoplasm] (Rattus norvegicus)

Homologues of Me3K10-HIST1H3A [nucleoplasm] (Plasmodium falciparum)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 10

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_066403.2, NP_001005464.1, NP_001116847.1

OpenTargets

ENSG00000203852, ENSG00000203811, ENSG00000183598

ENSEMBL

ENSP00000333277, ENSP00000385479, ENST00000403683, ENSP00000358154, ENST00000331491, ENST00000369158

HPA

ENSG00000203852-H3C15, ENSG00000183598-H3C13, ENSG00000203811-H3C14

PRO

Q71DI3

Pharos - Targets

Q71DI3

GlyGen

Q71DI3

PDB

3R93, 7BQZ, 6Y5E, 6T7C, 7PF2, 7PEZ, 7PF3, 8AAG, 6T7A, 7PEX, 6T79, 8AV6, 7PF0, 7PFF, 7PFA, 7PFC, 7PET, 7PEU, 7PEV, 4OUC, 7U53, 6X5A, 7U51, 7PFT, 7U50, 2X4X, 7JOA, 2IIJ, 8OL1, 4MZH, 8JLB, 5B0Y, 7PFV, 8JLD, 8ATF, 5BO0, 3AV1, 7BU9, 7XCR, 5VAC, 5CIU, 6Y5D, 7PEY, 6FML, 6T7D, 3QO2, 7JO9, 7PF4, 6T7B, 7JZV, 3MO8, 7PFD, 6ACE, 7PFE, 7PF6, 3DB3, 7PF5, 7PEW, 5B40, 7TAN, 8GRQ, 6XJD, 4MZF, 7U52, 6X59, 7PFX, 5B0Z, 2X4Y, 4MZG, 8HQY, 7YRD, 7PFU, 7XCT, 2X4W, 8HR1, 7XD0, 7PFW, 7UV9, 7UVA

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.704	4
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.576	4
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.576	5
UniProt:P29474 NOS3	9	2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (R-HSA-202139) 2xPalmC-MyrG-NOS3 [plasma membrane] (R-HSA-534993) 2xPalmC-MyrG-NOS3 [Golgi membrane] (R-HSA-203769) MyrG-NOS3 [cytosol] (R-HSA-203687) MyrG-NOS3 [Golgi membrane] (R-HSA-534995) NOS3 [cytosol] (R-HSA-202114) 2xPalmC-MyrG-NOS3 [endocytic vesicle membrane] (R-HSA-535007) 2xPalmC-MyrG-p-S633-NOS3 [plasma membrane] (R-HSA-9861341) 2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane] (R-HSA-9860783)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3

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