Proton-coupled histidine and di-peptide cotransport

Stable Identifier
R-HSA-428007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A bioinformatics approach identified two further human transporters, PHT1 and PHT2 (Botka CW et al, 2000). These two transporters may be located on the lysosomal membrane for the proton-coupled export of histidine and di-peptides from lysosomal protein degradation.
Literature References
PubMed ID Title Journal Year
11741232 Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics

Higaka, K, Wittig, TW, Nielsen, CU, Sadee, W, Amidon, GL, Graul, RC, Botka, CW

AAPS PharmSci 2000
Participants
Participates
Catalyst Activity

peptide:proton symporter activity of PHT cotransporters [lysosomal membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!