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CERS4 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-428138
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
LASS4, LAG1 homolog, ceramide synthase 4
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
Ceramide synthases transfer acyl-CoA onto sphingoid (Homo sapiens)
Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)
CERS4 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HA82 CERS4
Gene Names
CERS4, LASS4
Chain
chain:1-394
Reference Genes
BioGPS Gene:79603 CERS4
COSMIC (genes):CERS4 CERS4
CTD Gene:79603 CERS4
dbSNP Gene:79603 CERS4
ENSEMBL:ENSG00000090661 CERS4
HGNC:23747 CERS4
KEGG:hsa:79603 CERS4
Monarch:79603 CERS4
NCBI Gene:79603 CERS4
OMIM:615334 CERS4
UCSC:Q9HA82 CERS4
Reference Transcript
RefSeq:XM_011528295.2 CERS4
RefSeq:XM_011528294.2 CERS4
RefSeq:XM_011528290.2 CERS4
RefSeq:XM_011528293.2 CERS4
RefSeq:XM_011528291.2 CERS4
RefSeq:XM_017027304.1 CERS4
RefSeq:XM_011528292.2 CERS4
RefSeq:XM_017027303.1 CERS4
RefSeq:NM_024552.2 CERS4
RefSeq:XM_017027305.1 CERS4
Other Identifiers
11732516_a_at
11754372_x_at
16857851
218922_3p_s_at
218922_PM_s_at
218922_s_at
3819402
3819403
3819404
3819405
3819406
3819407
3819408
3819414
3819415
3819417
3819418
3819419
3819421
3819422
3819423
3819424
3819425
3819426
3819427
3819428
3819430
3819431
3819432
3819433
3819434
3819435
3819436
3819437
3819440
52955_at
79603
8025382
A_14_P110714
A_14_P132182
A_23_P153867
GE62791
GO:0003677
GO:0003824
GO:0005515
GO:0005634
GO:0005783
GO:0005789
GO:0006629
GO:0006665
GO:0016020
GO:0016740
GO:0030148
GO:0043226
GO:0046513
GO:0050291
HMNXSV003011388
HMNXSV003022233
PH_hs_0015462
TC19000144.hg
g13375716_3p_a_at
g13375716_3p_x_at
Participates
as a member of
Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
crsA [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
cers4 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
LAG1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
schlank [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CERS4 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CERS4 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
Homologues of CERS4 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
LAC1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
lag1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
lac1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
CERS4 [endoplasmic reticulum membrane]
(Bos taurus)
CERS4 [endoplasmic reticulum membrane]
(Canis familiaris)
CERS4 [endoplasmic reticulum membrane]
(Gallus gallus)
CERS4 [endoplasmic reticulum membrane]
(Plasmodium falciparum)
CERS4 [endoplasmic reticulum membrane]
(Sus scrofa)
Cers4 [endoplasmic reticulum membrane]
(Mus musculus)
Cers4 [endoplasmic reticulum membrane]
(Rattus norvegicus)
hyl-2 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
hyl-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cers4a [endoplasmic reticulum membrane]
(Danio rerio)
Cross References
Guide to Pharmacology - Targets
2477
ENSEMBL
ENST00000251363
,
ENST00000559450
,
ENSP00000251363
,
ENSP00000453509
OpenTargets
ENSG00000090661
IntEnz
2.3.1.24
HPA
ENSG00000090661-CERS4
PRO
Q9HA82
Pharos - Targets
Q9HA82
HMDB Protein
HMDBP11632
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
0.556
3
UniProt:P24593 IGFBP5
5
IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956738)
p-IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956988)
IGFBP5 [extracellular region]
(R-HSA-381414)
IGFBP5(21-163) [extracellular region]
(R-HSA-381415)
IGFBP5(164-272) [extracellular region]
(R-HSA-381478)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
UniProt:P78382 SLC35A1
2
SLC35A1 [Golgi membrane]
(R-HSA-727812)
SLC35A1 V93Cfs*17 [Golgi membrane]
(R-HSA-5651957)
0.556
3
UniProt:O00767 SCD
1
SCD [endoplasmic reticulum membrane]
(R-HSA-400117)
0.556
3
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
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