Reactome | CERS6 [endoplasmic reticulum membrane]

CERS6 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-428145

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

LASS6, LAG1 homolog, ceramide synthase 6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q6ZMG9 CERS6

Gene Names

CERS6, LASS6

Chain

chain:1-384

Reference Genes

BioGPS Gene:253782 CERS6

COSMIC (genes):CERS6 CERS6

CTD Gene:253782 CERS6

dbSNP Gene:253782 CERS6

ENSEMBL:ENSG00000172292 CERS6

ENSEMBL_homo_sapiens_GENE:ENSG00000172292.15 CERS6

HGNC:23826 CERS6

KEGG Gene (Homo sapiens):253782 CERS6

Monarch:253782 CERS6

NCBI Gene:253782 CERS6

OMIM:615336 CERS6

UCSC:Q6ZMG9 CERS6

Reference Transcript

Other Identifiers

11730440_at

11754581_s_at

11755520_s_at

16887179

212442_PM_s_at

212442_s_at

212446_PM_s_at

212446_s_at

235463_PM_s_at

235463_s_at

242019_PM_at

242019_at

2514120

2514121

2514123

2514124

2514139

2514140

2514143

2514160

2514173

2514176

2514182

2514183

2514184

2514203

2514204

2514205

2514206

2514207

2514208

2514209

2514210

253782

38630_at

47434_at

52653_at

75411_at

8046086

A_24_P289366

A_32_P5480

A_33_P3399870

GE56359

GE763971

GO:0003677

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006665

GO:0006954

GO:0016020

GO:0016740

GO:0030148

GO:0043226

GO:0046513

GO:0050291

HMNXSV003043596

Hs.101282.0.A1_3p_a_at

Hs.101282.0.A2_3p_a_at

Hs.118338.0.A1_3p_a_at

Hs.118338.1.A1_3p_at

ILMN_1767662

PH_hs_0018807

TC02000996.hg

Participates

as a member of

Ceramide synthases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

CERS6 [endoplasmic reticulum membrane] (Bos taurus)

CERS6 [endoplasmic reticulum membrane] (Canis familiaris)

CERS6 [endoplasmic reticulum membrane] (Gallus gallus)

CERS6 [endoplasmic reticulum membrane] (Plasmodium falciparum)

CERS6 [endoplasmic reticulum membrane] (Sus scrofa)

crsA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

LAG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

schlank [endoplasmic reticulum membrane] (Drosophila melanogaster)

cers6 [endoplasmic reticulum membrane] (Xenopus tropicalis)

hyl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

LAC1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

lag1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cers6 [endoplasmic reticulum membrane] (Mus musculus)

Cers6 [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of CERS6 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_982288.1, NP_001243055.1

Guide to Pharmacology - Targets

2479

OpenTargets

ENSG00000172292

HPA

ENSG00000172292-CERS6

GeneCards

Q6ZMG9

Ensembl

ENSP00000306579, ENSG00000172292, ENST00000305747, ENSP00000376453, ENST00000392687

PRO

Q6ZMG9

Pharos - Targets

Q6ZMG9

HMDB Protein

HMDBP11633

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41146 OPRL1	1	OPRL1 [plasma membrane] (R-HSA-374731)	0.632	3
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [tertiary granule membrane] (R-HSA-6803296) FPR2 [plasma membrane] (R-HSA-416408)	0.527	3
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:P30556 AGTR1	2	AGTR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869071) AGTR1 [plasma membrane] (R-HSA-374247)	0.508	2

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