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IGF2BP1 [cytosol]
Stable Identifier
R-HSA-428366
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Insulin-like growth factor 2 mRNA-binding protein 1, IF2B1_HUMAN, ZBP1, CRD-BP, VICKZ1
Icon
Locations in the PathwayBrowser for interactor UniProt:P42704 LRPPRC
Expand all
Metabolism of RNA (Homo sapiens)
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA (Homo sapiens)
IGF2BP1 binds specific RNAs (Homo sapiens)
IGF2BP1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
IGF2BP1 binds MAPK4 mRNA (Homo sapiens)
IGF2BP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZI8 IGF2BP1
Gene Names
IGF2BP1, CRDBP, VICKZ1, ZBP1
Chain
chain:1-577
Reference Genes
BioGPS Gene:10642 IGF2BP1
COSMIC (genes):IGF2BP1 IGF2BP1
CTD Gene:10642 IGF2BP1
dbSNP Gene:10642 IGF2BP1
ENSEMBL:ENSG00000159217 IGF2BP1
ENSEMBL_homo_sapiens_GENE:ENSG00000159217.10 IGF2BP1
HGNC:28866 IGF2BP1
KEGG Gene (Homo sapiens):10642 IGF2BP1
Monarch:10642 IGF2BP1
NCBI Gene:10642 IGF2BP1
OMIM:608288 IGF2BP1
UCSC:Q9NZI8 IGF2BP1
Reference Transcript
RefSeq:NM_001160423.1 IGF2BP1
RefSeq:NM_006546.3 IGF2BP1
Other Identifiers
10642
11727101_at
11727102_a_at
11727103_at
16835517
223689_PM_at
223689_at
227377_PM_at
227377_at
3725518
3725519
3725521
3725526
3725527
3725528
3725531
3725532
3725533
3725534
3725535
3725536
3725537
3725540
3725541
3725543
3725544
3725545
3725546
3725547
3725549
3725551
3725552
3725553
61347_at
64757_at
72854_at
8008151
83260_s_at
83983_at
A_14_P122163
A_23_P343954
A_23_P83498
GE733136
GE80369
GE88227
GO:0000932
GO:0001817
GO:0002181
GO:0003676
GO:0003723
GO:0003729
GO:0003730
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006403
GO:0006417
GO:0007399
GO:0010468
GO:0010494
GO:0010610
GO:0016071
GO:0017148
GO:0022013
GO:0030027
GO:0030154
GO:0030175
GO:0030424
GO:0030425
GO:0030426
GO:0042995
GO:0043025
GO:0043197
GO:0043226
GO:0045182
GO:0045202
GO:0048027
GO:0048471
GO:0048856
GO:0051028
GO:0070934
GO:0070937
GO:0097150
GO:0140059
GO:1900152
GO:1990247
GO:1990904
GO:2000767
HMNXSV003034929
Hs.24739.0.A1_3p_at
Hs.24739.0.A1_3p_x_at
ILMN_1733807
PH_hs_0004851
PH_hs_0039031
TC17000636.hg
TC17002261.hg
g7141071_3p_at
Participates
as an input of
IGF2BP1 binds MAPK4 mRNA (Homo sapiens)
IGF2BP1 binds specific RNAs (Homo sapiens)
as a component of
IGF2BP1:MAPK4 mRNA [cytosol] (Homo sapiens)
IGF2BP1:RNA [cytosol] (Homo sapiens)
Inferred To
Homologues of IGF2BP1 [cytosol]
(Caenorhabditis elegans)
Homologues of IGF2BP1 [cytosol]
(Plasmodium falciparum)
Homologues of IGF2BP1 [cytosol]
(Saccharomyces cerevisiae)
IGF2BP1 [cytosol]
(Bos taurus)
IGF2BP1 [cytosol]
(Canis familiaris)
IGF2BP1 [cytosol]
(Gallus gallus)
IGF2BP1 [cytosol]
(Plasmodium falciparum)
IGF2BP1 [cytosol]
(Sus scrofa)
Igf2bp1 [cytosol]
(Mus musculus)
Igf2bp1 [cytosol]
(Rattus norvegicus)
rnc1 [cytosol]
(Schizosaccharomyces pombe)
imph-1 [cytosol]
(Caenorhabditis elegans)
HEK2 [cytosol]
(Saccharomyces cerevisiae)
tofu-7 [cytosol]
(Caenorhabditis elegans)
PBP2 [cytosol]
(Saccharomyces cerevisiae)
Imp [cytosol]
(Drosophila melanogaster)
igf2bp1 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001153895.1
,
NP_006537.3
OpenTargets
ENSG00000159217
HPA
ENSG00000159217-IGF2BP1
GeneCards
Q9NZI8
Ensembl
ENST00000431824
,
ENST00000290341
,
ENSP00000290341
,
ENSG00000159217
,
ENSP00000389135
PRO
Q9NZI8
Pharos - Targets
Q9NZI8
PDB
3KRM
,
6QEY
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.677
8
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.677
7
UniProt:O95793 STAU1
0.649
7
UniProt:O00425 IGF2BP3
1
IGF2BP3 [cytosol]
(R-HSA-428313)
0.643
4
UniProt:O60506 HNRPQ
0.577
6
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.577
8
UniProt:Q15717 ELAVL1
6
ELAVL1 [nucleoplasm]
(R-HSA-450601)
p-S158,S221-ELAVL1 [nucleoplasm]
(R-HSA-450576)
p-S221,S318-ELAVL1 [nucleoplasm]
(R-HSA-450532)
ELAVL1 [cytosol]
(R-HSA-450582)
p-S221,S318-ELAVL1 [cytosol]
(R-HSA-450448)
p-S158,S221-ELAVL1 [cytosol]
(R-HSA-450376)
0.577
5
UniProt:Q9HCE1 MOV10
1
MOV10 [cytosol]
(R-HSA-427772)
0.564
2
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.527
4
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.527
2
UniProt:Q12926 ELAVL2
1
ELAVL2 [nucleoplasm]
(R-HSA-8850864)
0.527
3
UniProt:Q14103 HNRNPD
1
HNRNPD [nucleoplasm]
(R-HSA-71935)
0.527
2
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.527
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.527
2
UniProt:Q99729 ROAA
0.527
2
UniProt:P51991 HNRNPA3
1
HNRNPA3 [nucleoplasm]
(R-HSA-71931)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
4
UniProt:P26599 PTBP1
1
PTBP1 [nucleoplasm]
(R-HSA-71923)
0.527
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
3
UniProt:Q96PU8 QKI
2
QKI(1-504)-RAF1(278-648) fusion [cytosol]
(R-HSA-6802466)
QKI(1-504)-p-RAF1(278- 648) fusion [cytosol]
(R-HSA-6802546)
0.527
2
UniProt:Q9NUL3 STAU2
0.527
2
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.527
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.499
3
UniProt:Q8VDS3 CBX7
0.499
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
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