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SRGAP1 [cytosol]
Stable Identifier
R-HSA-428453
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SLIT-ROBO Rho GTPase-activating protein 1, SRGP1_HUMAN, ARHGAP13
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Inactivation of CDC42 and RAC1 (Homo sapiens)
Inactivation of CDC42 (Homo sapiens)
SLIT2:ROBO1:SRGAP [plasma membrane] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
SRGAP binds ROBO1:SLIT2 (Homo sapiens)
SLIT2:ROBO1:SRGAP [plasma membrane] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA GAPs [cytosol] (Homo sapiens)
SRGAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z6B7 SRGAP1
Gene Names
SRGAP1, ARHGAP13, KIAA1304
Chain
chain:1-1085
Reference Genes
BioGPS Gene:57522 SRGAP1
COSMIC (genes):SRGAP1 SRGAP1
CTD Gene:57522 SRGAP1
dbSNP Gene:57522 SRGAP1
ENSEMBL:ENSG00000196935 SRGAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000196935.10 SRGAP1
HGNC:17382 SRGAP1
KEGG Gene (Homo sapiens):57522 SRGAP1
Monarch:57522 SRGAP1
NCBI Gene:57522 SRGAP1
OMIM:606523 SRGAP1
UCSC:Q7Z6B7 SRGAP1
Reference Transcript
RefSeq:NM_020762.3 SRGAP1
RefSeq:NM_001346201.1 SRGAP1
Other Identifiers
11727977_a_at
11727978_at
1555875_PM_at
1555875_at
1555876_3p_at
1555876_PM_at
1555876_at
1569269_PM_s_at
1569269_s_at
16753426
227484_PM_at
227484_at
233888_PM_s_at
233888_s_at
3419642
3419643
3419644
3419645
3419679
3419680
3419681
3419690
3419698
3419699
3419704
3419705
3419709
3419710
3419717
3419719
3419720
3419722
3419723
3419724
3419728
3419729
3419732
3419733
3419734
3419735
3419737
3419738
3419739
3419756
3419757
3419759
3419761
3419762
3419764
3419766
3419768
42669_at
54664_at
57522
62780_at
7956759
A_23_P162449
GE53895
GE57002
GE896587
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0007165
GO:0023052
GO:0030336
GO:0048870
GO:0098772
HMNXSV003052344
Hs.155489.2.S1_3p_at
Hs.18995.1.S1_3p_a_at
Hs2.400041.1.S1_3p_s_at
Hs2.422911.1.S1_3p_at
ILMN_1677432
PH_hs_0017252
PH_hs_0033778
TC12000564.hg
TC12002414.hg
Participates
as a candidate of
RHOA GAPs [cytosol] (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
as a member of
SRGAP [cytosol] (Homo sapiens)
Inferred To
srgap1b [cytosol]
(Danio rerio)
srgp-1 [cytosol]
(Caenorhabditis elegans)
SRGAP1 [cytosol]
(Bos taurus)
SRGAP1 [cytosol]
(Canis familiaris)
SRGAP1 [cytosol]
(Gallus gallus)
SRGAP1 [cytosol]
(Sus scrofa)
srgap1 [cytosol]
(Xenopus tropicalis)
Srgap1 [cytosol]
(Mus musculus)
Srgap1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_065813.1
,
NP_001333130.1
OpenTargets
ENSG00000196935
HPA
ENSG00000196935-SRGAP1
GeneCards
Q7Z6B7
Ensembl
ENST00000631006
,
ENSP00000485752
,
ENSG00000196935
,
ENSP00000347198
,
ENST00000355086
PRO
Q7Z6B7
Pharos - Targets
Q7Z6B7
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.744
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.499
4
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