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PAK6 [cytosol]
Stable Identifier
R-HSA-428454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase PAK 6, PAK6_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Recruitment of PAK to NCK (Homo sapiens)
PAK [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
PAK [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD binds effectors at the plasma membrane (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOD:GTP:RHOD plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOH GTPase cycle (Homo sapiens)
RHOH binds effectors at the plasma membrane (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOH:GTP:RHOH effectors [plasma membrane] (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
PAK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQU5 PAK6
Gene Names
PAK6, PAK5
Chain
chain:1-681
Reference Genes
BioGPS Gene:106821730 PAK6
BioGPS Gene:56924 PAK6
COSMIC (genes):PAK6 PAK6
CTD Gene:106821730 PAK6
CTD Gene:56924 PAK6
dbSNP Gene:106821730 PAK6
dbSNP Gene:56924 PAK6
ENSEMBL:ENSG00000137843 PAK6
ENSEMBL_homo_sapiens_GENE:ENSG00000137843.12 PAK6
HGNC:16061 PAK6
KEGG Gene (Homo sapiens):106821730 PAK6
KEGG Gene (Homo sapiens):56924 PAK6
Monarch:106821730 PAK6
Monarch:56924 PAK6
NCBI Gene:106821730 PAK6
NCBI Gene:56924 PAK6
OMIM:608110 PAK6
UCSC:Q9NQU5 PAK6
Reference Transcript
RefSeq:NM_020168.5 PAK6
RefSeq:NM_001128628.2 PAK6
RefSeq:NM_001128629.2 PAK6
RefSeq:NM_001276717.1 PAK6
RefSeq:NM_001276718.1 PAK6
Other Identifiers
106821730
11722501_a_at
11722502_a_at
11737975_x_at
11742045_a_at
11745930_a_at
1555310_PM_a_at
1555310_a_at
219461_PM_at
219461_at
3589733
3589734
3589745
3589757
3589758
3589759
3589764
3589765
3589771
3589772
3589775
3589777
3589779
3589781
3589783
3589784
3589785
3589786
56924
59704_at
7982688
A_24_P159227
GE56918
GO:0000166
GO:0001650
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007010
GO:0007612
GO:0007613
GO:0007626
GO:0012501
GO:0014069
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030054
GO:0030154
GO:0035556
GO:0036211
GO:0043226
GO:0043408
GO:0045296
GO:0048856
GO:0050877
GO:0106310
GO:0140058
GO:0140096
GO:1990138
HMNXSV003058322
Hs.21420.0.S2_3p_s_at
ILMN_1708223
PH_hs_0001854
Participates
as a member of
RHOV effectors [cytosol] (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
as a candidate of
PAK [cytosol] (Homo sapiens)
Inferred To
Homologues of PAK6 [cytosol]
(Dictyostelium discoideum)
Homologues of PAK6 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PAK6 [cytosol]
(Schizosaccharomyces pombe)
Pak6 [cytosol]
(Rattus norvegicus)
PAK6 [cytosol]
(Bos taurus)
PAK6 [cytosol]
(Caenorhabditis elegans)
PAK6 [cytosol]
(Canis familiaris)
PAK6 [cytosol]
(Danio rerio)
PAK6 [cytosol]
(Dictyostelium discoideum)
PAK6 [cytosol]
(Drosophila melanogaster)
PAK6 [cytosol]
(Mus musculus)
PAK6 [cytosol]
(Saccharomyces cerevisiae)
PAK6 [cytosol]
(Schizosaccharomyces pombe)
PAK6 [cytosol]
(Sus scrofa)
PAK6 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_064553.1
,
NP_001122101.1
,
NP_001263647.1
,
NP_001122100.1
,
NP_001263646.1
ZINC - World Drugs
PAK6_HUMAN
Guide to Pharmacology - Targets
2137
OpenTargets
ENSG00000137843
ZINC - FDA approved
PAK6_HUMAN
ZINC - Substances
PAK6_HUMAN
ZINC - Biogenic
PAK6_HUMAN
ZINC target
Q9NQU5
PRO
Q9NQU5
PDB
2C30
,
4KS8
,
6QDS
,
2ODB
,
4KS7
,
6QDR
ZINC - Investigational
PAK6_HUMAN
GeneCards
Q9NQU5
HPA
ENSG00000137843-PAK6
Ensembl
ENSP00000406873
,
ENST00000455577
,
ENST00000560346
,
ENSP00000401153
,
ENST00000260404
,
ENSG00000137843
,
ENST00000558658
,
ENST00000453867
,
ENST00000441369
,
ENSP00000409465
,
ENST00000542403
,
ENSP00000456785
,
ENSP00000260404
,
ENSP00000439597
,
ENSP00000453858
Pharos - Targets
Q9NQU5
ZINC - Predictions - Purchasable
PAK6_HUMAN
HMDB Protein
HMDBP01253
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.744
5
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.659
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
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