Reactome | PAK5 [cytosol]

PAK5 [cytosol]

Stable Identifier

R-HSA-428459

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PAK7, Serine/threonine-protein kinase PAK 7, PAK7_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Activation of RAC1 (Homo sapiens)
        
        Recruitment of PAK to NCK (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK5 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P286 PAK5

Gene Names

PAK5, KIAA1264, PAK7

Chain

chain:1-719

Reference Genes

BioGPS Gene:57144 PAK5

COSMIC (genes):PAK5 PAK5

CTD Gene:57144 PAK5

dbSNP Gene:57144 PAK5

ENSEMBL:ENSG00000101349 PAK5

ENSEMBL:ENSG00000101349.17 PAK5

HGNC:15916 PAK5

KEGG Gene (Homo sapiens):57144 PAK5

Monarch:57144 PAK5

NCBI Gene:57144 PAK5

OMIM:608038 PAK5

UCSC:Q9P286 PAK5

Reference Transcript

Other Identifiers

11730406_a_at

11739447_a_at

16917139

210721_PM_s_at

210721_s_at

213990_PM_s_at

213990_s_at

3897279

3897281

3897282

3897285

3897286

3897288

3897289

3897291

3897293

3897300

3897309

3897316

3897321

3897326

3897328

3897329

3897330

3897331

39213_at

57144

8064952

A_24_P344666

GE53856

GO:0000166

GO:0001558

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006468

GO:0006915

GO:0007010

GO:0007165

GO:0007612

GO:0007613

GO:0007626

GO:0008283

GO:0012501

GO:0016043

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0023052

GO:0031965

GO:0035556

GO:0036211

GO:0043226

GO:0043408

GO:0045202

GO:0048870

GO:0050877

GO:0106310

GO:0140096

GO:2001237

HMNXSV003003927

Hs.32539.1.S1_3p_a_at

ILMN_1770938

ILMN_1803655

PH_hs_0002749

TC20000615.hg

g7649809_3p_a_at

Participates

as a member of

as a candidate of

PAK [cytosol] (Homo sapiens)

Other forms of this molecule

PAK7 [plasma membrane]

Inferred To

PAK5 [cytosol] (Bos taurus)

PAK5 [cytosol] (Caenorhabditis elegans)

PAK5 [cytosol] (Canis familiaris)

PAK5 [cytosol] (Danio rerio)

PAK5 [cytosol] (Dictyostelium discoideum)

PAK5 [cytosol] (Drosophila melanogaster)

PAK5 [cytosol] (Gallus gallus)

PAK5 [cytosol] (Mus musculus)

PAK5 [cytosol] (Rattus norvegicus)

PAK5 [cytosol] (Saccharomyces cerevisiae)

PAK5 [cytosol] (Schizosaccharomyces pombe)

PAK5 [cytosol] (Sus scrofa)

PAK5 [cytosol] (Xenopus tropicalis)

Homologues of PAK5 [cytosol] (Dictyostelium discoideum)

Homologues of PAK5 [cytosol] (Saccharomyces cerevisiae)

Homologues of PAK5 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_016883451.1, XP_016883450.1, NP_065074.1, XP_016883453.1, XP_016883449.1, NP_817127.1, XP_016883454.1, XP_016883452.1

ZINC - World Drugs

PAK7_HUMAN

Guide to Pharmacology - Targets

2138

OpenTargets

ENSG00000101349

ZINC - FDA approved

PAK7_HUMAN

ZINC - Substances

PAK7_HUMAN

ZINC target

Q9P286

ZINC - Biogenic

PAK7_HUMAN

PRO

Q9P286

PDB

2F57

ZINC - Investigational

PAK7_HUMAN

IntEnz

2.7.11.1

GeneCards

Q9P286

HPA

ENSG00000101349-PAK5

Ensembl

ENSP00000322957, ENST00000378429, ENSP00000367679, ENST00000353224, ENSG00000101349, ENST00000378423, ENSP00000367686

Pharos - Targets

Q9P286

ZINC - Predictions - Purchasable

PAK7_HUMAN

HMDB Protein

HMDBP01170

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.743	5
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.666	5
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.666	4
UniProt:Q96SW2 CRBN	1	CRBN [cytosol] (R-HSA-8863300)	0.666	4
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.666	4
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:P48730 CSNK1D	3	CSNK1D [nucleoplasm] (R-HSA-421305) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717) CSNK1D [cytosol] (R-HSA-380315)	0.556	3
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.527	2

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