Reactome | PAK4 [cytosol]

PAK4 [cytosol]

Stable Identifier

R-HSA-428461

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase PAK 4, PAK4_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Activation of RAC1 (Homo sapiens)
        
        Recruitment of PAK to NCK (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK4 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:NCK:PAK [plasma membrane] (Homo sapiens)
        
        PAK [cytosol] (Homo sapiens)
        
        PAK4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O96013 PAK4

Gene Names

PAK4, KIAA1142

Chain

chain:1-591

Reference Genes

BioGPS Gene:10298 PAK4

COSMIC (genes):PAK4 PAK4

CTD Gene:10298 PAK4

dbSNP Gene:10298 PAK4

ENSEMBL:ENSG00000130669 PAK4

ENSEMBL:ENSG00000130669.17 PAK4

HGNC:16059 PAK4

KEGG Gene (Homo sapiens):10298 PAK4

Monarch:10298 PAK4

NCBI Gene:10298 PAK4

OMIM:605451 PAK4

UCSC:O96013 PAK4

Reference Transcript

Other Identifiers

10298

11718917_a_at

11718918_x_at

11750738_x_at

11750961_a_at

11751001_a_at

16861930

203154_3p_s_at

203154_PM_s_at

203154_s_at

215326_3p_at

215326_PM_at

215326_at

33814_PM_at

33814_at

3832831

3832841

3832842

3832843

3832846

3832847

3832848

3832849

3832850

3832851

3832852

3832856

3832857

3832858

3832859

3832860

3832861

3832862

3832863

3832864

3832866

8028583

A_14_P114095

A_24_P313822

GE62187

GO:0000166

GO:0001558

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005794

GO:0005829

GO:0005912

GO:0005925

GO:0006468

GO:0006915

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0012501

GO:0016043

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0023052

GO:0030154

GO:0035556

GO:0036211

GO:0043226

GO:0043408

GO:0045766

GO:0048856

GO:0048870

GO:0060996

GO:0071407

GO:0098609

GO:0098631

GO:0098641

GO:0106310

GO:0140096

GO:2000352

HMNXSV003022937

Hs.20447.2.S1_3p_at

ILMN_1728887

ILMN_1763187

ILMN_2354673

PH_hs_0030823

TC19000537.hg

g7382497_3p_a_at

g7382497_3p_s_at

Participates

as a candidate of

as a member of

Inferred To

Pak4 [cytosol] (Rattus norvegicus)

Homologues of PAK4 [cytosol] (Dictyostelium discoideum)

Homologues of PAK4 [cytosol] (Saccharomyces cerevisiae)

Homologues of PAK4 [cytosol] (Schizosaccharomyces pombe)

PAK4 [cytosol] (Bos taurus)

PAK4 [cytosol] (Caenorhabditis elegans)

PAK4 [cytosol] (Canis familiaris)

PAK4 [cytosol] (Danio rerio)

PAK4 [cytosol] (Dictyostelium discoideum)

PAK4 [cytosol] (Drosophila melanogaster)

PAK4 [cytosol] (Mus musculus)

PAK4 [cytosol] (Saccharomyces cerevisiae)

PAK4 [cytosol] (Schizosaccharomyces pombe)

PAK4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001014831.1, NP_005875.1, XP_011524621.1, NP_001014835.1, XP_011524618.1, XP_011524620.1, NP_001014834.1, NP_001014832.1, XP_011524619.1, XP_011524622.1

ZINC - World Drugs

PAK4_HUMAN

Guide to Pharmacology - Targets

2136

OpenTargets

ENSG00000130669

ZINC - FDA approved

PAK4_HUMAN

ZINC - Substances

PAK4_HUMAN

ZINC target

O96013

ZINC - Biogenic

PAK4_HUMAN

PRO

O96013

PDB

4FIG, 4FIF, 5XVF, 2X4Z, 4O0X, 4XBR, 4JDK, 4NJD, 4O0Y, 4XBU, 2CDZ, 4JDJ, 7CP3, 7S46, 4FIE, 5VED, 5XVG, 2Q0N, 4FIJ, 7CP4, 6WLX, 7S48, 4JDI, 5UPK, 6WLY, 8AHG, 4JDH, 5VEE, 2OV2, 5VEF, 5BMS, 5I0B, 5UPL, 4FII, 8AHH, 4FIH, 2J0I, 8AHI, 4APP, 2BVA, 5ZJW, 4O0V, 7CMB, 4L67, 5XVA

ZINC - Investigational

PAK4_HUMAN

GeneCards

O96013

HPA

ENSG00000130669-PAK4

Ensembl

ENSP00000469413, ENSG00000130669, ENST00000360442, ENST00000358301, ENSP00000326864, ENST00000593690, ENST00000599386, ENST00000321944, ENST00000599470, ENSP00000353625, ENSP00000351049, ENSP00000470284, ENSP00000471157

Pharos - Targets

O96013

ZINC - Predictions - Purchasable

PAK4_HUMAN

HMDB Protein

HMDBP01267

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.864	7
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.825	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.744	5
UniProt:O00401 WASL	4	WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012) N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672)	0.619	8
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	4