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SRGAP3 [cytosol]
Stable Identifier
R-HSA-428463
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SLIT-ROBO Rho GTPase-activating protein 3, SRGP2_HUMAN, ARHGAP14
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Inactivation of CDC42 and RAC1 (Homo sapiens)
Inactivation of CDC42 (Homo sapiens)
SLIT2:ROBO1:SRGAP [plasma membrane] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
SRGAP binds ROBO1:SLIT2 (Homo sapiens)
SLIT2:ROBO1:SRGAP [plasma membrane] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
SRGAP3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43295 SRGAP3
Gene Names
SRGAP3, ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRGAP2
Chain
chain:1-1099
Reference Genes
BioGPS Gene:9901 SRGAP3
COSMIC (genes):SRGAP2 SRGAP3
COSMIC (genes):SRGAP3 SRGAP3
CTD Gene:9901 SRGAP3
dbSNP Gene:9901 SRGAP3
ENSEMBL:ENSG00000196220 SRGAP3
HGNC:19744 SRGAP3
Monarch:9901 SRGAP3
NCBI Gene:9901 SRGAP3
OMIM:606525 SRGAP3
UCSC:O43295 SRGAP3
Reference Transcript
RefSeq:NM_001033117.2 SRGAP3
RefSeq:NM_014850.3 SRGAP3
Other Identifiers
11724961_a_at
11724962_a_at
11761646_at
1563595_3p_at
1563595_PM_at
1563595_at
16950470
209794_PM_at
209794_at
215550_3p_at
215550_PM_at
215550_at
232869_3p_at
232869_PM_at
232869_at
2662088
2662089
2662090
2662091
2662092
2662096
2662097
2662098
2662099
2662102
2662103
2662104
2662105
2662107
2662109
2662110
2662111
2662112
2662114
2662115
2662116
2662117
2662118
2662119
2662120
2662129
2662131
2662132
2662134
2662137
2662138
2662139
2662140
2662141
2662144
2662150
2662153
2662154
2662158
2662159
2662183
2662184
2662190
2662191
2662192
2662193
2662194
2662220
2662221
2662227
37563_at
8085164
84139_at
9901
A_23_P358410
A_24_P153869
A_33_P3368540
GE53167
GE604552
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0007165
GO:0030336
GO:0051056
GO:0098772
GO:0098794
HMNXSV003005715
HMNXSV003011848
HMNXSV003024948
Hs.272324.0.S1_3p_at
Hs.272324.0.S1_3p_x_at
Hs.272563.0.S1_3p_x_at
Hs2.375684.1.S1_3p_x_at
ILMN_1722923
ILMN_2400644
ILMN_2400648
PH_hs_0026908
TC03003372.hg
g2887442_3p_at
p11275
p11277
Participates
as a candidate of
CDC42 GAPs [cytosol] (Homo sapiens)
as a member of
RAC1 GAPs [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
Inferred To
srgp-1 [cytosol]
(Caenorhabditis elegans)
Srgap3 [cytosol]
(Mus musculus)
Srgap3 [cytosol]
(Rattus norvegicus)
srgap3 [cytosol]
(Xenopus tropicalis)
SRGAP3 [cytosol]
(Bos taurus)
SRGAP3 [cytosol]
(Canis familiaris)
SRGAP3 [cytosol]
(Gallus gallus)
SRGAP3 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000360413
,
ENST00000383836
,
ENSP00000373347
,
ENSP00000353587
OpenTargets
ENSG00000196220
HPA
ENSG00000196220-SRGAP3
PRO
O43295
Pharos - Targets
O43295
Orphanet
SRGAP3
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.544
2
UniProt:O35179 Sh3gl2
5
Sh3gl2 [Golgi membrane]
(R-RNO-351189)
Sh3gl2 [clathrin-coated endocytic vesicle membrane]
(R-RNO-2130629)
Sh3gl2 [cytosol]
(R-RNO-182958)
Endophilin [plasma membrane]
(R-RNO-182026)
Sh3gl2 [plasma membrane]
(R-RNO-177495)
0.544
3
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