Recruitment of Profilin by Ena/VASP proteins

Stable Identifier
R-HSA-428534
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Recruitment of Profilin by Ena/VASP proteins
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Ena/VASP proteins (ENAH, EVL1 and VASP) enhance actin filament elongation via the recruitment of profilin:actin complexes to the tips of spreading lamellipodia. Profilin (PFN1 or PFN2) binds to the central proline rich domain of an Ena/VASP protein (Bashaw et al. 2000).

Literature References
PubMed ID Title Journal Year
10892742 Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Pawson, T, Bashaw, GJ, Goodman, CS, Kidd, T, Murray, D

Cell 2000
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Orthologous Events
Recruitment of Profilin by Ena/VASP proteins (Danio rerio)
Recruitment of Profilin by Ena/VASP proteins (Mus musculus)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-06)
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