Reactome | Vesicular inhibitory amino acid transport

Vesicular inhibitory amino acid transport

Stable Identifier

R-HSA-428625

Type

Reaction [transition]

Species

Homo sapiens

Compartment

synaptic vesicle membrane

ReviewStatus

5/5

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Vesicular inhibitory amino acid transport

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Gamma-Aminobutyric acid (GABA) is the major inhibitory
transmitter of the vertebrate retina. The gene SLC32A1 encodes the vesicular inhibitory amino acid transporter (VIAAT, also called vesicular GABA transporter VGAT) (Jellali A et al, 2002). VIAAT is a proton-coupled amino acid antiporter, uptaking the inhibitory neurotransmitters GABA and glycine into synaptic vesicles in exchange for protons. This process is driven by the H+-ATPase, providing the driving force for uptake of these neurotransmitters. The protein is expressed throughout the terminal ends of horizontal cells of the retina.

Literature References

PubMed ID	Title	Journal	Year
12115694	Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina Sahel, JA, Stussi-Garaud, C, Dreyfus, H, Picaud, S, Jellali, A, Rendon, A, Gasnier, B	J Comp Neurol	2002