Reactome | PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

Stable Identifier

R-HSA-428690

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]

ReviewStatus

5/5

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PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

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Phospholipid phosphatase 2 (PLPP2, PPAP2A, LPP3) enzyme associated with the plasma membrane catalyzes the hydrolysis of extracellular sphingosine 1-phosphate (S1P) to form sphingosine and orthophosphate. The reaction is essential for removing S1P from plasma and cell uptake of sphingosine (Roberts et al., 1998; Zhao et al., 2007; reviewed by Tang et al., 2015).

Literature References

PubMed ID	Title	Journal	Year
9705349	Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. Morris, AJ, Roberts, R, Sciorra, VA	J Biol Chem	1998
25814022	Lipid phosphate phosphatases and their roles in mammalian physiology and pathology Tang, X, Benesch, MG, Brindley, DN	J Lipid Res	2015
17379599	Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1 Garcia, JG, Gorshkova, I, Watkins, T, Bittman, R, Kalari, SK, Zhao, Y, Natarajan, V, Sun, C, Brindley, DN, He, D, Usatyuk, PV, Berdyshev, EV	J Biol Chem	2007