Reactome | p-T180,Y182-MAPK14 [cytosol]

p-T180,Y182-MAPK14 [cytosol]

Stable Identifier

R-HSA-428935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-MAP kinase p38 alpha, MAP kinase p38 alpha (activated), MAPK14, Mitogen-activated protein kinase 14, MK14_HUMAN, pp38 alpha

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)
        
        PLK2, MAPK14 [cytosol] (Homo sapiens)
        
        p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Regulation of mRNA stability by proteins that bind AU-rich elements (Homo sapiens)
  - KSRP (KHSRP) binds and destabilizes mRNA (Homo sapiens)
    - MAP kinase p38 phosphorylates KSRP (Homo sapiens)
      - Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
        
        p-p38 MAPK alpha/beta [cytosol] (Homo sapiens)
        
        p-T180,Y182-MAPK14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16539 MAPK14

Gene Names

MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Chain

initiator methionine:, chain:2-360

Reference Genes

COSMIC (genes):MAPK14 MAPK14

dbSNP Gene:1432 MAPK14

ENSEMBL:ENSG00000112062 MAPK14

Participates

as a member of

as a candidate of

Phospho-p38 MAPK [cytosol] (Homo sapiens)

as an output of

Other forms of this molecule

MAPK14 [ficolin-1-rich granule lumen]

MAPK14 [extracellular region]

MAPK14 [secretory granule lumen]

MAPK14 [nucleoplasm]

MAPK14 [cytosol]

p-T180,Y182-MAPK14 [nucleoplasm]

Inferred To

phospho-p-T180,Y182-MAPK14 [cytosol] (Bos taurus)

phospho-p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)

phospho-p-T180,Y182-MAPK14 [cytosol] (Canis familiaris)

phospho-p-T180,Y182-MAPK14 [cytosol] (Danio rerio)

phospho-p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)

phospho-p-T180,Y182-MAPK14 [cytosol] (Drosophila melanogaster)

phospho-p-T180,Y182-MAPK14 [cytosol] (Rattus norvegicus)

phospho-p-T180,Y182-MAPK14 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T180,Y182-MAPK14 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T180,Y182-MAPK14 [cytosol] (Sus scrofa)

phospho-p-T180,Y182-MAPK14 [cytosol] (Xenopus tropicalis)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Caenorhabditis elegans)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Dictyostelium discoideum)

Homologues of p-T180,Y182-MAPK14 [cytosol] (Drosophila melanogaster)

phospho-gskl-2 [cytosol] (Caenorhabditis elegans)

phospho-MAP kinase p38 alpha [cytosol] (Mus musculus)

phospho-MAPK14 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 180

Coordinate

180

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 182

Coordinate

182

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.93	15
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723) MAPKAPK3 [cytosol] (R-HSA-187764)	0.914	15
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.829	9
UniProt:P46734 MAP2K3	3	MAP2K3 [cytosol] (R-HSA-168051) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.802	7
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.798	7
UniProt:Q9HBH9 MKNK2			0.788	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.779	6
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.767	4
UniProt:Q8NEM7 SUPT20H	1	SUPT20H [nucleoplasm] (R-HSA-3662286)	0.756	5
UniProt:O75147 OBSL1	1	OBSL1 [cytosol] (R-HSA-8955929)	0.725	4
UniProt:O43257 ZNHI1			0.72	7
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.713	4
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.691	5
UniProt:Q15256 PTPRR			0.664	4
UniProt:Q9BY84 DUSP16	3	Ac-55-DUSP16 [cytosol] (R-HSA-9636576) DUSP16 [nucleoplasm] (R-HSA-5675337) DUSP16 [cytosol] (R-HSA-5675336)	0.659	3
UniProt:Q9H0W5 CCDC8	1	CCDC8 [cytosol] (R-HSA-8955915)	0.643	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.643	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.623	4
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.59	2
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.564	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9H869 YYAP1			0.553	2
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.547	2
UniProt:Q6PJG2 MDEAS			0.547	2
UniProt:O75582 RPS6KA5	3	p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683) RPS6KA5 [nucleoplasm] (R-HSA-198657) RPS6KA5 [cytosol] (R-HSA-772525)	0.547	3
UniProt:Q14814 MEF2D	1	MEF2D [nucleoplasm] (R-HSA-445328)	0.547	2
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.547	3
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.527	2
UniProt:P13639 EEF2	10	EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [cytosol] (R-HSA-9619231)	0.527	2
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	2
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.508	2
UniProt:Q07352 ZFP36L1	3	p-S54,S92,S203-p-ZFP36L1 [cytosol] (R-HSA-450384) ZFP36L1 [cytosol] (R-HSA-450547) p-S92,S203-ZFP36L1 [cytosol] (R-HSA-450618)	0.508	2

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