Reactome | ALOX5 is phosphorylated by MAPKAP2

ALOX5 is phosphorylated by MAPKAP2

Stable Identifier

R-HSA-429016

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Arachidonate 5-lipoxygenase (ALOX5) catalyzes the first step in leukotriene biosynthesis and has a key role in inflammatory processes. ALOX5 is phosphorylated by MAPKAPK2; MAPKAPK2 is stimulated by arachidonate.

Literature References

PubMed ID	Title	Journal	Year
11844797	Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2) Steinhilber, D, Rådmark, O, Werz, O, Szellas, D	J Biol Chem	2002
10779545	5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases Rådmark, O, Klemm, J, Werz, O, Samuelsson, B	Proc Natl Acad Sci U S A	2000