Reactome | Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6

Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6

Stable Identifier

R-HSA-429571

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6

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The human SLC5A11 gene encodes a high affinity myo-inositol transporter (SMIT2, SGLT6) (Ostlund RE et al, 1996; Roll P et al, 2002). It can transport myo-inositol and D-chiro-inositol, together with two Na+ ions. It was thought SGLT6 could transport glucose but there is no evidence for this so far (Lin X et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
12039040	New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families Roll, P, Massacrier, A, Pereira, S, Robaglia-Schlupp, A, Cau, P, Szepetowski, P	Gene	2002
8626564	A stereospecific myo-inositol/D-chiro-inositol transporter in HepG2 liver cells. Identification with D-chiro-[3-3H]inositol Ostlund RE, Jr, Seemayer, R, Gupta, S, Kimmel, R, Ostlund, EL, Sherman, WR	J Biol Chem	1996
19032932	Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells Lin, X, Ma, L, Fitzgerald, RL, Ostlund RE, Jr	Arch Biochem Biophys	2009