SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-429594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
Synonyms
Sodium- and chloride-dependent choline transport by CHT
ReviewStatus
5/5
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SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol
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The human SLC5A7 gene encodes a sodium- and chloride-dependent, high affinity choline transporter, CHT (Apparsundaram et al. 2000). CHT transports choline (Cho) from the extracellular space into neuronal cells and is dependent on Na+ and Cl- ions for transport (Okuda & Haga 2000). Choline uptake is the rate-limiting step in acetylcholine synthesis.
Literature References
PubMed ID Title Journal Year
11068039 Functional characterization of the human high-affinity choline transporter

Haga, T, Okuda, T

FEBS Lett 2000
11027560 Molecular cloning of a human, hemicholinium-3-sensitive choline transporter

Ferguson, SM, Blakely, RD, George AL, Jr, Apparsundaram, S

Biochem Biophys Res Commun 2000
Participants
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Output
Participates
as an event of
Catalyst Activity

choline transmembrane transporter activity of SLC5A7 [plasma membrane]

Physical Entity
SLC5A7 [plasma membrane] (Homo sapiens)
Activity
choline transmembrane transporter activity (GO:0015220)
Orthologous Events
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)
SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)
Authored
Jassal, B  (2009-07-17)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2009-07-17)
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