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CERT1-2 complex dissociates
Stable Identifier
R-HSA-429694
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
CERT1-2 complex dissociates (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CERT1-2 (ceramide transfer protein, isoform 2) can dissociate from its complex in the endoplasmic reticulum membrane with VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) and is released into the cytosol (Kawano et al. 2006; reviewed by Kumagai & Hanada, 2019).
Literature References
PubMed ID
Title
Journal
Year
31254361
Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites
Hanada, K
,
Kumagai, K
FEBS Lett
2019
16895911
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT
Kawano, M
,
Hanada, K
,
Kumagai, K
,
Nishijima, M
J Biol Chem
2006
Participants
Input
ceramide:CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane]
(Homo sapiens)
Output
ceramide:CERT1-2 [cytosol]
(Homo sapiens)
PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Sphingolipid de novo biosynthesis (Homo sapiens)
Orthologous Events
CERT1-2 complex dissociates (Bos taurus)
CERT1-2 complex dissociates (Danio rerio)
CERT1-2 complex dissociates (Drosophila melanogaster)
Authored
D'Eustachio, P (2009-08-21)
Reviewed
Luberto, C (2009-11-19)
Hannun, YA (2009-11-19)
Jassal, B (2009-08-21)
D'Eustachio, P (2023-10-24)
Created
D'Eustachio, P (2009-07-19)
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