Reactome | CERT1-2 complex dissociates

CERT1-2 complex dissociates

Stable Identifier

R-HSA-429694

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CERT1-2 (ceramide transfer protein, isoform 2) can dissociate from its complex in the endoplasmic reticulum membrane with VAPA or VAPB (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) and is released into the cytosol (Kawano et al. 2006; reviewed by Kumagai & Hanada, 2019).

Literature References

PubMed ID	Title	Journal	Year
31254361	Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites Hanada, K, Kumagai, K	FEBS Lett	2019
16895911	Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT Kawano, M, Hanada, K, Kumagai, K, Nishijima, M	J Biol Chem	2006