Reactome | CSNK1G2 phosphorylates p-CERT1-2

CSNK1G2 phosphorylates p-CERT1-2

Stable Identifier

R-HSA-429714

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP

ReviewStatus

5/5

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Cytosolic CSNK1G2 (casein kinase 1, gamma 2) catalyzes the phosphorylation of multiple serine and threonine residues of “CERT” (ceramide transfer protein) already phosphorylated on serine-132 (Tomishige et al. 2009). This reaction has the effect of inhibiting ceramide transport from the endoplasmic reticulum to the Golgi apparatus as multiphospho-CERT is unable to bind ceramides or associate with the Golgi membrane (reviewed by Kumagai & Hanada, 2019).

Literature References

PubMed ID	Title	Journal	Year
19005213	Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin Hanada, K, Kusuda, J, Kumagai, K, Tomishige, N, Nishijima, M	Mol Biol Cell	2009
31254361	Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites Hanada, K, Kumagai, K	FEBS Lett	2019