Reactome | VAPB [endoplasmic reticulum membrane]

VAPB [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-429718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

VAMP-associated protein B

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95292 VAPB

Gene Names

VAPB, UNQ484/PRO983

Chain

initiator methionine:, chain:2-243

Reference Genes

BioGPS Gene:9217 VAPB

COSMIC (genes):VAPB VAPB

CTD Gene:9217 VAPB

dbSNP Gene:9217 VAPB

ENSEMBL:ENSG00000124164 VAPB

ENSEMBL_homo_sapiens_GENE:ENSG00000124164.16 VAPB

HGNC:12649 VAPB

KEGG Gene (Homo sapiens):9217 VAPB

Monarch:9217 VAPB

NCBI Gene:9217 VAPB

OMIM:605704 VAPB

UCSC:O95292 VAPB

Reference Transcript

Other Identifiers

11717583_s_at

11717584_a_at

11749369_a_at

11758066_s_at

16915231

202549_PM_at

202549_at

202550_PM_s_at

202550_s_at

225923_PM_at

225923_at

3890914

3890915

3890916

3890917

3890918

3890922

3890929

3890931

3890933

3890934

3890936

3890937

3890938

3890939

3890940

3890941

3890942

40940_at

41757_at

65637_at

8063620

9217

A_14_P121711

A_33_P3365586

GE54746

GE855235

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006874

GO:0006888

GO:0006986

GO:0007029

GO:0008017

GO:0008092

GO:0016020

GO:0016192

GO:0019076

GO:0019899

GO:0023052

GO:0030301

GO:0030968

GO:0033149

GO:0036498

GO:0042803

GO:0043226

GO:0044790

GO:0044828

GO:0044829

GO:0044830

GO:0045070

GO:0045296

GO:0046725

GO:0046982

GO:0048487

GO:0055065

GO:0061024

GO:0061817

GO:0090114

GO:0090158

GO:0098542

HMNXSV003052877

Hs.159161.2.A1_3p_at

Hs.182625.0.S3_3p_at

ILMN_1678459

PH_hs_0010780

TC20000458.hg

TC20001316.hg

g4759301_3p_a_at

Participates

as a candidate of

as a member of

VAPA/B [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

VAPB [Golgi membrane]

Inferred To

VAPB [endoplasmic reticulum membrane] (Bos taurus)

VAPB [endoplasmic reticulum membrane] (Canis familiaris)

VAPB [endoplasmic reticulum membrane] (Gallus gallus)

VAPB [endoplasmic reticulum membrane] (Sus scrofa)

scs2 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Vap33 [endoplasmic reticulum membrane] (Drosophila melanogaster)

scs22 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

vapb [endoplasmic reticulum membrane] (Danio rerio)

vapb [endoplasmic reticulum membrane] (Xenopus tropicalis)

fan [endoplasmic reticulum membrane] (Drosophila melanogaster)

Vapb [endoplasmic reticulum membrane] (Mus musculus)

Vapb [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of VAPB [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of VAPB [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of VAPB [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Homologues of VAPB [endoplasmic reticulum membrane] (Sus scrofa)

SCS2 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

SCS22 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001182606.1, NP_004729.1

OpenTargets

ENSG00000124164

GeneCards

O95292

HPA

ENSG00000124164-VAPB

Ensembl

ENSP00000417175, ENSP00000379147, ENST00000395802, ENSG00000124164, ENST00000475243

PRO

O95292

Pharos - Targets

O95292

Orphanet

15704

PDB

3IKK, 2MDK

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.725	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.671	4
UniProt:P22059 OSBP	1	OSBP [cytosol] (R-HSA-429725)	0.643	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.64	12
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.599	9
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	2
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.527	3
UniProt:Q9BX63 BRIP1	2	p-S990,Ac-K1249-BRIP1 [nucleoplasm] (R-HSA-5687710) BRIP1 [cytosol] (R-HSA-2564781)	0.527	3
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	3
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.527	4
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.527	3
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.527	2
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.527	4
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.527	4
UniProt:Q03137 Epha4	2	Epha4 [plasma membrane] (R-MMU-3928415) phospho-p-Y596,Y602-EPHA4 [plasma membrane] (R-MMU-3928352)	0.499	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.483	3

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