PPM1L dephosphorylates multiphospho-CERT1-2

Stable Identifier
R-HSA-429730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate
ReviewStatus
5/5
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PPM1L dephosphorylates multiphospho-CERT1-2
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PPM1L (protein phosphatase 1-like) catalyzes the dephosphorylation of multiphospho-“CERT” (ceramide transfer protein) that is complexed with it in the endoplasmic reticulum membrane (Saito et al. 2008; reviewed by Kumagai & Hanada, 2019). This reinstates binding of ceramide to and its transport by CERT.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of p-S,S132,T-CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane]

Physical Entity
p-S,S132,T-CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)
PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)
PPM1L dephosphorylates multiphospho-CERT1-2 (Drosophila melanogaster)
Authored
D'Eustachio, P  (2009-08-21)
Reviewed
Luberto, C  (2009-11-19)
Hannun, YA  (2009-11-19)
Jassal, B  (2009-08-21)
D'Eustachio, P  (2023-10-24)
Created
D'Eustachio, P  (2009-07-20)
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