Reactome | SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-429749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in), acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in), butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in), propanoate(out) + 2 Na(+)(out) = propanoate(in) + 2 Na(+)(in), pyruvate(out) + 2 Na(+)(out) = pyruvate(in) + 2 Na(+)(in)

ReviewStatus

5/5

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SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

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The human tumour suppressor gene SLC5A8 encodes sodium-coupled monocarboxylate transporter 1, SMCT1 (also called AIT) and is abundantly expressed in the colon (Coady et al. 2004, Myauchi et al. 2004). When the human protein is expressed in Xenopus oocytes, it was found to transport small monocarboxylates and carboxylate drugs, co-transporting Na+ ions electrogenically (2 Na+ ions co-transported with 1 carboxylate). Covarrubias et al. (2021) describe SLC5A8 as one of the transporters that feeds extracellular NCA into the Preiss-Handler pathway for nicotinamide biosynthesis.

Literature References

PubMed ID	Title	Journal	Year
33353981	NAD⁺ metabolism and its roles in cellular processes during ageing Covarrubias, AJ, Perrone, R, Grozio, A, Verdin, E	Nat Rev Mol Cell Biol	2021
15090606	The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter Coady, MJ, Chang, MH, Charron, FM, Plata, C, Wallendorff, B, Sah, JF, Markowitz, SD, Romero, MF, Lapointe, JY	J Physiol	2004
14966140	Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids Miyauchi, S, Gopal, E, Fei, YJ, Ganapathy, V	J Biol Chem	2004