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2xPalmC-SGMS2 [plasma membrane]
Stable Identifier
R-HSA-429775
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SGMS2, sphingomyelin synthase 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Sphingolipid de novo biosynthesis (Homo sapiens)
SGMS2 transfers phosphocholine onto ceramide (Homo sapiens)
2xPalmC-SGMS2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NHU3 SGMS2
Gene Names
SGMS2, SMS2
Chain
chain:1-365
Reference Genes
BioGPS Gene:166929 SGMS2
COSMIC (genes):SGMS2 SGMS2
CTD Gene:166929 SGMS2
dbSNP Gene:166929 SGMS2
ENSEMBL:ENSG00000164023 SGMS2
ENSEMBL_homo_sapiens_GENE:ENSG00000164023.15 SGMS2
HGNC:28395 SGMS2
KEGG Gene (Homo sapiens):166929 SGMS2
Monarch:166929 SGMS2
NCBI Gene:166929 SGMS2
OMIM:611574 SGMS2
UCSC:Q8NHU3 SGMS2
Reference Transcript
RefSeq:NM_001136258.1 SGMS2
RefSeq:XM_011531701.2 SGMS2
RefSeq:XM_017007840.1 SGMS2
RefSeq:XM_011531698.2 SGMS2
RefSeq:XM_017007839.1 SGMS2
RefSeq:NM_001136257.1 SGMS2
RefSeq:NM_152621.5 SGMS2
RefSeq:XM_011531700.2 SGMS2
RefSeq:XM_011531699.2 SGMS2
RefSeq:XM_011531702.2 SGMS2
Other Identifiers
11722153_s_at
11722154_a_at
11722155_a_at
166929
16969558
227038_PM_at
227038_at
242963_PM_at
242963_at
243141_PM_at
243141_at
2738665
2738672
2738680
2738681
2738682
2738683
2738684
2738685
2738687
2738689
2738690
2738691
2738692
2738693
2738694
2738695
2738696
47772_at
50148_r_at
66849_at
8096733
A_23_P326204
GE550025
GO:0000139
GO:0002950
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005794
GO:0005886
GO:0006629
GO:0006665
GO:0006686
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0016780
GO:0030148
GO:0030500
GO:0033188
GO:0043226
GO:0046513
GO:0047493
GO:0048856
GO:1905373
HMNXSV003004786
HMNXSV003041260
Hs.129379.0.A1_3p_at
Hs.29567.0.A1_3p_at
Hs.62666.0.A1_3p_at
ILMN_1685176
PH_hs_0029842
TC04000553.hg
Inferred To
sgms2 [plasma membrane]
(Xenopus tropicalis)
sms-2 [plasma membrane]
(Caenorhabditis elegans)
Sgms2 [plasma membrane]
(Mus musculus)
Sgms2 [plasma membrane]
(Rattus norvegicus)
SGMS2 [plasma membrane]
(Bos taurus)
SGMS2 [plasma membrane]
(Canis familiaris)
SGMS2 [plasma membrane]
(Gallus gallus)
SGMS2 [plasma membrane]
(Sus scrofa)
sms-3 [plasma membrane]
(Caenorhabditis elegans)
2xPalmC-SGMS2 [plasma membrane]
(Danio rerio)
2xPalmC-SGMS2 [plasma membrane]
(Plasmodium falciparum)
Homologues of 2xPalmC-SGMS2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of 2xPalmC-SGMS2 [plasma membrane]
(Plasmodium falciparum)
sms-1 [plasma membrane]
(Caenorhabditis elegans)
sms-5 [plasma membrane]
(Caenorhabditis elegans)
Modified Residues
Name
S-palmitoyl-L-cysteine at 343
Coordinate
343
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 348
Coordinate
348
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Cross References
RefSeq
XP_011530000.1
,
NP_001129730.1
,
XP_016863329.1
,
NP_689834.1
,
XP_016863328.1
,
XP_011530004.1
,
XP_011530003.1
,
XP_011530002.1
,
NP_001129729.1
,
XP_011530001.1
Guide to Pharmacology - Targets
2521
OpenTargets
ENSG00000164023
IntEnz
2.7.8.27
HPA
ENSG00000164023-SGMS2
GeneCards
Q8NHU3
ZINC target
Q8NHU3
Ensembl
ENSP00000378178
,
ENST00000359079
,
ENSP00000351981
,
ENSG00000164023
,
ENST00000394686
,
ENSP00000378176
,
ENSP00000508566
,
ENST00000394684
,
ENST00000690982
PRO
Q8NHU3
Pharos - Targets
Q8NHU3
Orphanet
29675
HMDB Protein
HMDBP00770
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q59EV6 Q59EV6
0.556
3
UniProt:P23763-3 VAMP1
0.556
3
UniProt:O95159 ZFPL1
0.556
3
UniProt:Q9UBY5 LPAR3
1
LPAR3 [plasma membrane]
(R-HSA-419379)
0.556
3
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