Reactome | DCP2 [cytosol]

DCP2 [cytosol]

Stable Identifier

R-HSA-429937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

mRNA-decapping enzyme 2, DCP2_HUMAN

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - PERK regulates gene expression (Homo sapiens)
      - ATF4 activates genes in response to endoplasmic reticulum stress (Homo sapiens)
        
        Expression of IL-8 (Homo sapiens)
        
        KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
        
        DCP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IU60 DCP2

Gene Names

DCP2, NUDT20

Chain

chain:1-420

Reference Genes

BioGPS Gene:167227 DCP2

COSMIC (genes):DCP2 DCP2

CTD Gene:167227 DCP2

dbSNP Gene:167227 DCP2

ENSEMBL:ENSG00000172795 DCP2

HGNC:24452 DCP2

KEGG:hsa:167227 DCP2

Monarch:167227 DCP2

NCBI Gene:167227 DCP2

OMIM:609844 DCP2

UCSC:Q8IU60 DCP2

Reference Transcript

Participates

as an input of

as a component of

Inferred To

DCP2 [cytosol] (Bos taurus)

DCP2 [cytosol] (Caenorhabditis elegans)

DCP2 [cytosol] (Canis familiaris)

DCP2 [cytosol] (Drosophila melanogaster)

DCP2 [cytosol] (Gallus gallus)

DCP2 [cytosol] (Mus musculus)

DCP2 [cytosol] (Plasmodium falciparum)

DCP2 [cytosol] (Saccharomyces cerevisiae)

DCP2 [cytosol] (Sus scrofa)

dcp2 [cytosol] (Danio rerio)

dcp2 [cytosol] (Dictyostelium discoideum)

dcp2 [cytosol] (Xenopus tropicalis)

Dcp2 [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000172795

ENSEMBL

ENST00000515408, ENSG00000172795, ENSP00000425770, ENST00000389063, ENSP00000373715

IntEnz

3.6.1.62

HPA

ENSG00000172795-DCP2

GeneCards

DCP2

PRO

Q8IU60

Pharos - Targets

Q8IU60

HMDB Protein

HMDBP08710

PDB

5QP3, 5QOQ, 5QP2, 5QOR, 5QOJ, 5QOI, 5QOT, 5QOL, 5MP0, 5QOK, 5QP1, 5QOO, 5QP0, 5QOP, 5QOH, 5QOM, 5QON, 5QOZ, 5QOY, 5QP7, 5QOU, 5QP6, 5QOV, 5QOS, 5QP5, 5QP4, 5QOW, 5QP9, 5QP8, 5QOX, 5QPC, 5QPB, 5QPA

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.942	18
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.86	11
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.659	5
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.641	3
UniProt:Q3UJB9	1	Edc4 [cytosol] (R-MMU-429963)	0.564	2
UniProt:Q9NPJ4 PNRC2	1	PNRC2 [cytosol] (R-HSA-8879146)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.527	3

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