Reactome | mRNA decay by 3' to 5' exoribonuclease

mRNA decay by 3' to 5' exoribonuclease

Stable Identifier

R-HSA-429958

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap.

Literature References

PubMed ID	Title	Journal	Year
14749774	The enzymes and control of eukaryotic mRNA turnover Song, H, Parker, R	Nat Struct Mol Biol	2004
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ	Cell Biochem Biophys	2004
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
11283721	The cap-to-tail guide to mRNA turnover Wormington, M, Wilusz, CJ, Peltz, SW	Nat Rev Mol Cell Biol	2001