Reactome | DDX6 [cytosol]

DDX6 [cytosol]

Stable Identifier

R-HSA-430032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Probable ATP-dependent RNA helicase DDX6, DDX6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P26196 DDX6

Gene Names

DDX6, HLR2, RCK

Chain

chain:1-483

Reference Genes

BioGPS Gene:1656 DDX6

COSMIC (genes):DDX6 DDX6

CTD Gene:1656 DDX6

dbSNP Gene:1656 DDX6

ENSEMBL:ENSG00000110367 DDX6

ENSEMBL_homo_sapiens_GENE:ENSG00000110367.14 DDX6

HGNC:2747 DDX6

KEGG Gene (Homo sapiens):1656 DDX6

Monarch:1656 DDX6

NCBI Gene:1656 DDX6

OMIM:600326 DDX6

UCSC:P26196 DDX6

Reference Transcript

Other Identifiers

11718967_at

11718968_a_at

11718969_a_at

1656

16745085

204909_PM_at

204909_at

225549_PM_at

225549_at

2947762

2947768

3393943

3393945

3393947

3393948

3393949

3393950

3393951

3393952

3393953

3393954

3393955

3393957

3393959

3393960

3393961

3393964

3393970

3393971

3393973

3393974

3393975

3393978

3393979

3495819

3495822

36283_at

52993_at

70792_at

7952103

A_23_P203201

A_24_P215407

D17532_at

GE57104

GE86447

GE86532

GO:0000166

GO:0000932

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0010494

GO:0016020

GO:0016442

GO:0016787

GO:0016887

GO:0017148

GO:0019074

GO:0019827

GO:0019904

GO:0030154

GO:0030182

GO:0031047

GO:0033962

GO:0034063

GO:0035278

GO:0036464

GO:0043226

GO:0045296

GO:0045665

GO:0048856

GO:0140098

GO:0140657

HMNXSV003003073

Hs.271541.0.S1_3p_at

ILMN_1777340

PH_hs_0023351

PH_hs_0032397

TC11002353.hg

TC11003376.hg

Z11685_s_at

g13514828_3p_at

Participates

as a component of

DCP1-DCP2 Decapping Complex [cytosol] (Homo sapiens)

Inferred To

Ddx6 [cytosol] (Rattus norvegicus)

DDX6 [cytosol] (Bos taurus)

DDX6 [cytosol] (Caenorhabditis elegans)

DDX6 [cytosol] (Canis familiaris)

DDX6 [cytosol] (Dictyostelium discoideum)

DDX6 [cytosol] (Drosophila melanogaster)

DDX6 [cytosol] (Gallus gallus)

DDX6 [cytosol] (Mus musculus)

DDX6 [cytosol] (Plasmodium falciparum)

DDX6 [cytosol] (Saccharomyces cerevisiae)

DDX6 [cytosol] (Sus scrofa)

DDX6 [cytosol] (Xenopus tropicalis)

ddx6 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001244120.1, XP_005271474.1, NP_004388.2

OpenTargets

ENSG00000110367

IntEnz

3.6.4.13

GeneCards

P26196

HPA

ENSG00000110367-DDX6

Ensembl

ENSP00000478754, ENSP00000433704, ENST00000534980, ENSP00000442266, ENST00000620157, ENST00000526070, ENSG00000110367

PRO

P26196

Pharos - Targets

P26196

Orphanet

28730

HMDB Protein

HMDBP11693

PDB

2WAX, 6F9S, 4CRW, 5ANR, 1VEC, 2WAY, 4CT4, 4CT5, 6S8S

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.92	12
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.781	7
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.773	11
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.755	14
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.723	10
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.708	4
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.666	4
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.623	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.564	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.556	3
UniProt:Q9BUH8 BEGAIN	1	BEGAIN [cytosol] (R-HSA-6794250)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.537	5
UniProt:P62266 RPS23	3	3OHP62-RPS23 [nucleoplasm] (R-HSA-9630773) RPS23 [nucleoplasm] (R-HSA-6791209) RPS23 [cytosol] (R-HSA-72353)	0.527	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.527	3
UniProt:Q12905 ILF2	5	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [cytosol] (R-HSA-9836392)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	2
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.527	2
UniProt:P62081 RPS7	2	RPS7 [nucleoplasm] (R-HSA-6790635) RPS7 [cytosol] (R-HSA-72383)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [nucleoplasm] (R-HSA-6790669) RPS14 [cytosol] (R-HSA-72333)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.527	2
UniProt:P46776 RPL27A	3	3OHH39-RPL27A [nucleoplasm] (R-HSA-9630970) RPL27A [nucleoplasm] (R-HSA-9630984) RPL27A [cytosol] (R-HSA-72442)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.527	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	3
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.491	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.462	3

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